Phenotypes associated with this allele

• Allele Symbol: Del(16Dgcr2-Hira)3Aam
• Allele Name: deletion, Chr 16, Alea A Mills 3
• Allele ID: MGI:3798964
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Del(16Dgcr2-Hira)3Aam/+	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J	MGI:3802827
ht2	Del(16Dgcr2-Hira)3Aam/+	involves: 129S7/SvEvBrd	MGI:5766948
ht3	Del(16Dgcr2-Hira)3Aam/+	involves: 129S7/SvEvBrd * C57BL/6J	MGI:5519120

Genotype
MGI:3802827

ht1

• Allelic Composition: Del(16Dgcr2-Hira)3Aam/+
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:136969 )

• some mice die at or around birth of cardiovacsular abnormalities

behavior/neurological

abnormal contextual conditioning behavior ( J:136969 )

• mice freeze less than wild-type mice in a contextual fear-conditioning test

abnormal cued conditioning behavior ( J:136969 )

• mice freeze less than wild-type mice in a cued fear-conditioning test

abnormal spatial working memory ( J:136969 )

• mice exhibit decreased arm choice accuracy compared to wild-type mice

increased anxiety-related response ( J:136969 )

• male mice, but not female mice, travel more I the margins and less in the center of an open field compared to wild-type males

• in a light-dark transition test, male mice spend more time in the dark phase than wild-type male mice

hyperactivity ( J:136969 )

nervous system

abnormal dendrite morphology ( J:136969 )

• mice exhibit a reduction in the number and size of dendritic spines and decreased dendritic complexity of CA1 pyramidal neurons compared to in wild-type mice

decreased prepulse inhibition ( J:136969 )

• mice exhibit a deficit in prepulse inhibition compared to in wild-type mice

cardiovascular system

abnormal cardiovascular system morphology ( J:136969 )

• some mice die at or around birth of cardiovacsular abnormalities

Genotype
MGI:5766948

ht2

• Allelic Composition: Del(16Dgcr2-Hira)3Aam/+
• Genetic Background: involves: 129S7/SvEvBrd

nervous system

abnormal dendrite morphology ( J:141432 )

• reduction in dendritic complexity in primary cultured neurons, with hippocampal neurons exhibiting a 38% decrease in the number of primary dendrites, a 45% decrease in the number of branch points and a decrease in the total length of dendrites

• 8 week old mice show a decrease in the number of branch points in the basal dendritic tree of CA1 neurons

abnormal dendritic spine morphology ( J:141432 )

• reduction in the mushroom spine density in CA1 pyramidal neurons and in primary cultured neurons

• average spine head width is decreased by 23% and the average length is decreased by 18.5% in primary cultured neurons

• CA1 pyramidal neurons show a decrease in spine width but not spine length

abnormal synapse morphology ( J:141432 )

• reduction in the density of glutamatergic synapses in vitro and in vivo

decreased miniature excitatory postsynaptic current frequency ( J:141432 )

• miniature excitatory postsynaptic currents (MEPSCs) occur at lower frequencies in primary cultured hippocampal neurons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
DiGeorge syndrome		DOID:11198	OMIM:188400	J:141432

Genotype
MGI:5519120

ht3

• Allelic Composition: Del(16Dgcr2-Hira)3Aam/+
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

behavior/neurological

abnormal spatial working memory ( J:158957 )

• mutants require more training in the T-maze task than controls to reach criterion, indicating a learning impairment

nervous system

abnormal nervous system physiology ( J:158957 )

• hippocampal-prefrontal synchrony is reduced during working memory performance on the discrete-trial T-maze task

• phase-locking of prefrontal neurons to hippocampal theta oscillations and coherence of prefrontal and hippocampal local field potentials are reduced

• coherence is lower in mutants before training when tested on center-arm runs during habituation, indicating that hippocampal-prefrontal circuit synchrony is impaired at baseline

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:158957