All Phenotypes Dgcr8<Gt(XH157)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dgcr8^Gt(XH157)Byg
gene trap XH157, BayGenomics
MGI:3798965

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dgcr8^Gt(XH157)Byg/Dgcr8⁺	B6.129P2-Dgcr8^Gt(XH157)Byg	MGI:5451009
ht2	Dgcr8^Gt(XH157)Byg/Dgcr8⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:3802830
cx3	Dgcr8^Gt(XH157)Byg/Dgcr8⁺ Tg(Thy1-EGFP)MJrs/0	involves: 129P2/OlaHsd * C57BL/6J * CBA	MGI:3802829

Allelic Composition	Dgcr8^Gt(XH157)Byg/Dgcr8⁺
Genetic Background	B6.129P2-Dgcr8^Gt(XH157)Byg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8^Gt(XH157)Byg mutation (1 available); any Dgcr8 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

enhanced long-term potentiation ( J:190908 )

• increased at 16 weeks of age but not at 8-10 weeks of age

• however, basal synaptic transmission is normal

Allelic Composition	Dgcr8^Gt(XH157)Byg/Dgcr8⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8^Gt(XH157)Byg mutation (1 available); any Dgcr8 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal spatial working memory ( J:136969 )

• mice exhibit decreased arm choice accuracy compared to wild-type mice

nervous system

abnormal dendrite morphology ( J:136969 )

• mice exhibit a reduction in the number of dendritic spines and mushroom spine dendritic complexity of CA1 pyramidal neurons compared to in wild-type mice

decreased prepulse inhibition ( J:136969 )

• mice exhibit a deficit in prepulse inhibition compared to in wild-type mice

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:136969 )

N	• despite abnormal prepulse inhibition, mice exhibit normal hearing

Allelic Composition	Dgcr8^Gt(XH157)Byg/Dgcr8⁺ Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8^Gt(XH157)Byg mutation (1 available); any Dgcr8 mutation (67 available)
Tg(Thy1-EGFP)MJrs mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dendrite morphology ( J:136969 )

• while length is normal, mushroom spine width in the CA1 pyramidal spines is decreased compared to in wild-type mice

• complexity of the basal dendritic tree of pyramidal neurons is reduced compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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