Phenotypes associated with this allele

• Allele Symbol: Grin1^Rgsc174
• Allele Name: RIKEN Genomic Sciences Center, 174
• Allele ID: MGI:3798977
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin1^Rgsc174/Grin1^Rgsc174	C57BL/6J-Grin1^Rgsc174	MGI:4457488
ht2	Grin1^Rgsc174/Grin1^+	(D2.B6-Grin1^Rgsc174 x C57BL/6J)F1	MGI:4457489
ht3	Grin1^Rgsc174/Grin1^+	C57BL/6J-Grin1^Rgsc174	MGI:4457487
ht4	Grin1^Rgsc174/Grin1^+	involves: C57BL/6JJcl * DBA/2JJcl	MGI:3798979

Genotype
MGI:4457488

hm1

• Allelic Composition: Grin1^Rgsc174/Grin1^Rgsc174
• Genetic Background: C57BL/6J-Grin1^Rgsc174

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:160947 )

• mice die from E17 to 4 weeks postnatally

postnatal lethality, incomplete penetrance ( J:160947 )

• mice die from E17 to 4 weeks postnatally

nervous system

abnormal neuron physiology ( J:160947 )

• cultured cortical neurons exhibit higher maximum calcium influx levels than wild-type neurons

• the duration of half-maximal calcium levels are longer than in wild-type neurons

Genotype
MGI:4457489

ht2

• Allelic Composition: Grin1^Rgsc174/Grin1⁺
• Genetic Background: (D2.B6-Grin1^Rgsc174 x C57BL/6J)F1

behavior/neurological

behavior/neurological phenotype ( J:160947 )

N • mice exhibit normal response in a resident-intruder test

Genotype
MGI:4457487

ht3

• Allelic Composition: Grin1^Rgsc174/Grin1⁺
• Genetic Background: C57BL/6J-Grin1^Rgsc174

behavior/neurological

behavior/neurological phenotype ( J:160947 )

N • mice exhibit normal anxiety in a light-dark transition test and spend the same amount of time in the center of an open field as wild-type mice

abnormal behavioral response to xenobiotic ( J:160947 )

• D,l-methylphenidate hydrochloride (MPH)-treated mice exhibit reduced locomotor activity unlike similarly treated wild-type mice

increased exploration in new environment ( J:160947 )

• mice exhibit increased exploration of a tube filled with marbles compared with wild-type mice

• however, time spent exploring the object is normal

hyperactivity ( J:160947 )

• mice exhibit increased activity in an open field test and home cage during the dark period compared with wild-type mice

• however, mice exhibit normal rest-activity cycles under standard light-dark cycle

abnormal social investigation ( J:160947 )

• mice exhibit reduced exploration interacting with other mice compared with wild-type mice

nervous system

abnormal neuron physiology ( J:160947 )

• more c-Fos immunoreactive cells are found in the prelimbic cortex than in wild-type mice

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:160947 )

• D,l-methylphenidate hydrochloride (MPH)-treated mice exhibit a lesser increase in c-Fos immunoreactive cells in the dorsal striatum than similarly treated wild-type mice

• MPH-treated mice exhibit a decrease in c-Fos immunoreactive cells in the prelimbic cortex compared with similarly treated wild-type mice

Genotype
MGI:3798979

ht4

• Allelic Composition: Grin1^Rgsc174/Grin1⁺
• Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

behavior/neurological

impaired passive avoidance behavior ( J:133634 )

• mice with this mutation exhibit a deficit of the passive avoidance response

hyperactivity ( J:133634 )

• mice heterozygous for this mutation exhibit hyperactivity in the home cage

• heterozygous mutants exhibit hyperactivity in the open field