Analysis Tools
immune system
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• impaired formation of follicular dendritic cell networks and germinal centers following immunization with sheep red blood cells
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• produce low titers of sheep red blood cell antibodies after immunization compared to wild-type controls
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• in response to poly(I:C) or LPS injection, compared to controls
• impairment in LPS-induce TNF response is not as severe as in mice homozygous for Myd88tm1Aki
• however, TNF levels following administration of CpG DNA are similar to controls
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• cultured splenocytes and bone marrow-derived dendritic cells produce less IL6 in response to poly(I:C)
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• increased susceptibility to L. monocytogenes-induced lethality compared to wild-type controls but not as susceptible as mice homozygous for Tnfrsf1atm1Mak
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homeostasis/metabolism
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• in response to poly(I:C) or LPS injection, compared to controls
• impairment in LPS-induce TNF response is not as severe as in mice homozygous for Myd88tm1Aki
• however, TNF levels following administration of CpG DNA are similar to controls
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• cultured splenocytes and bone marrow-derived dendritic cells produce less IL6 in response to poly(I:C)
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• decrease in sensitivity to hepatocyte apoptosis and liver failure induced by a combination of TNF and D-galactosamine
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hematopoietic system
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• impaired formation of follicular dendritic cell networks and germinal centers following immunization with sheep red blood cells
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• produce low titers of sheep red blood cell antibodies after immunization compared to wild-type controls
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