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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pcntm239Asp
mutation 239, Andrew S Peterson
MGI:3799303
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Gad1tm1.1Tama/Gad1+
Pcntm239Asp/Pcntm239Asp 		involves: C57BL/6 * C57BL/6J * CBA * FVB/N MGI:4440844
cx2
 		Pcntm239Asp/Pcntm239Asp
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802492
cx3
 		Pcntm239Asp/Pcnt+
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802494


Genotype
MGI:4440844
cx1
Allelic
Composition		 Gad1tm1.1Tama/Gad1+
Pcntm239Asp/Pcntm239Asp
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad1tm1.1Tama mutation (2 available); any Gad1 mutation (65 available)
Pcntm239Asp mutation (0 available); any Pcnt mutation (159 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal neuronal migration ( J:158418 )
• cultured interneurons from brain slices exhibit reduced and slower cell migration to the olfactory bulb compared with wild-type interneurons
• at E13.5, Gad67-GFP+ interneurons in the rostral ventral forebrain exhibit decreased net rate of migration, shorter somal translocation, fewer translocation per hour, longer pauses, and fewer direction changes compared with wild-type interneurons
• at E15.5, migration of dorsal lateral ganglionic eminence-derived interneurons is disrupted compared to in wild-type mice
• at E18.5, cells in the anterior subventricular zone exhibit decreased migration to the olfactory bulb compared with wild-type cells
• mice exhibit ectopic streaks of Gad67(Gad1)-GFP+ interneurons extending radially from the anterior subventricular zone in the rostral cortex unlike in wild-type mice
abnormal neuronal precursor proliferation ( J:158418 )
• at E14.5 and E17.5, mice exhibit fewer proliferation cells at the ventricular surface and increased proliferating cells at the cortical plate compared with wild-type mice

limbs/digits/tail

cellular
increased apoptosis ( J:158418 )
• between E10.5 and E15.5, mice exhibit increased apoptosis throughout the brain and body compared with wild-type mice
abnormal neuronal migration ( J:158418 )
• cultured interneurons from brain slices exhibit reduced and slower cell migration to the olfactory bulb compared with wild-type interneurons
• at E13.5, Gad67-GFP+ interneurons in the rostral ventral forebrain exhibit decreased net rate of migration, shorter somal translocation, fewer translocation per hour, longer pauses, and fewer direction changes compared with wild-type interneurons
• at E15.5, migration of dorsal lateral ganglionic eminence-derived interneurons is disrupted compared to in wild-type mice
• at E18.5, cells in the anterior subventricular zone exhibit decreased migration to the olfactory bulb compared with wild-type cells
• mice exhibit ectopic streaks of Gad67(Gad1)-GFP+ interneurons extending radially from the anterior subventricular zone in the rostral cortex unlike in wild-type mice
abnormal neuronal precursor proliferation ( J:158418 )
• at E14.5 and E17.5, mice exhibit fewer proliferation cells at the ventricular surface and increased proliferating cells at the cortical plate compared with wild-type mice

growth/size/body
embryonic growth retardation ( J:158418 )

embryo




Genotype
MGI:3802492
cx2
Allelic
Composition		 Pcntm239Asp/Pcntm239Asp
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcntm239Asp mutation (0 available); any Pcnt mutation (159 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex morphology ( J:136795 )
• at E14.5, mice exhibit abnormal interneuron migration in the cerebral cortex
• the crispness of the boundary between the subventricular zone and the stream of migrating cells is lost

limbs/digits/tail
polydactyly ( J:136795 )
• anterior




Genotype
MGI:3802494
cx3
Allelic
Composition		 Pcntm239Asp/Pcnt+
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcntm239Asp mutation (0 available); any Pcnt mutation (159 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:136795 )
• mortality among young adults is increased compared to in wild-type mice

behavior/neurological

nervous system




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory