About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pcntm239Asp
mutation 239, Andrew S Peterson
MGI:3799303
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Gad1tm1.1Tama/Gad1+
Pcntm239Asp/Pcntm239Asp 		involves: C57BL/6 * C57BL/6J * CBA * FVB/N MGI:4440844
cx2
 		Pcntm239Asp/Pcntm239Asp
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802492
cx3
 		Pcntm239Asp/Pcnt+
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802494


Genotype
MGI:4440844
cx1
Allelic
Composition		 Gad1tm1.1Tama/Gad1+
Pcntm239Asp/Pcntm239Asp
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad1tm1.1Tama mutation (2 available); any Gad1 mutation (65 available)
Pcntm239Asp mutation (0 available); any Pcnt mutation (159 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal neuronal migration ( J:158418 )
• cultured interneurons from brain slices exhibit reduced and slower cell migration to the olfactory bulb compared with wild-type interneurons
• at E13.5, Gad67-GFP+ interneurons in the rostral ventral forebrain exhibit decreased net rate of migration, shorter somal translocation, fewer translocation per hour, longer pauses, and fewer direction changes compared with wild-type interneurons
• at E15.5, migration of dorsal lateral ganglionic eminence-derived interneurons is disrupted compared to in wild-type mice
• at E18.5, cells in the anterior subventricular zone exhibit decreased migration to the olfactory bulb compared with wild-type cells
• mice exhibit ectopic streaks of Gad67(Gad1)-GFP+ interneurons extending radially from the anterior subventricular zone in the rostral cortex unlike in wild-type mice
abnormal neuronal precursor proliferation ( J:158418 )
• at E14.5 and E17.5, mice exhibit fewer proliferation cells at the ventricular surface and increased proliferating cells at the cortical plate compared with wild-type mice

limbs/digits/tail

cellular
increased apoptosis ( J:158418 )
• between E10.5 and E15.5, mice exhibit increased apoptosis throughout the brain and body compared with wild-type mice
abnormal neuronal migration ( J:158418 )
• cultured interneurons from brain slices exhibit reduced and slower cell migration to the olfactory bulb compared with wild-type interneurons
• at E13.5, Gad67-GFP+ interneurons in the rostral ventral forebrain exhibit decreased net rate of migration, shorter somal translocation, fewer translocation per hour, longer pauses, and fewer direction changes compared with wild-type interneurons
• at E15.5, migration of dorsal lateral ganglionic eminence-derived interneurons is disrupted compared to in wild-type mice
• at E18.5, cells in the anterior subventricular zone exhibit decreased migration to the olfactory bulb compared with wild-type cells
• mice exhibit ectopic streaks of Gad67(Gad1)-GFP+ interneurons extending radially from the anterior subventricular zone in the rostral cortex unlike in wild-type mice
abnormal neuronal precursor proliferation ( J:158418 )
• at E14.5 and E17.5, mice exhibit fewer proliferation cells at the ventricular surface and increased proliferating cells at the cortical plate compared with wild-type mice

growth/size/body
embryonic growth retardation ( J:158418 )

embryo




Genotype
MGI:3802492
cx2
Allelic
Composition		 Pcntm239Asp/Pcntm239Asp
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcntm239Asp mutation (0 available); any Pcnt mutation (159 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex morphology ( J:136795 )
• at E14.5, mice exhibit abnormal interneuron migration in the cerebral cortex
• the crispness of the boundary between the subventricular zone and the stream of migrating cells is lost

limbs/digits/tail
polydactyly ( J:136795 )
• anterior




Genotype
MGI:3802494
cx3
Allelic
Composition		 Pcntm239Asp/Pcnt+
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcntm239Asp mutation (0 available); any Pcnt mutation (159 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:136795 )
• mortality among young adults is increased compared to in wild-type mice

behavior/neurological

nervous system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory