Phenotypes associated with this allele

• Allele Symbol: Pcnt^m275Asp
• Allele Name: mutation 275, Andrew S Peterson
• Allele ID: MGI:3799305
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Pcnt^m275Asp/Pcnt^m275Asp Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802482
cx2	Pcnt^m275Asp/Pcnt^+ Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802483

Genotype
MGI:3802482

cx1

• Allelic Composition: Pcnt^m275Asp/Pcnt^m275Asp; Tg(Rr291-lacZ)#Mekk/0
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:136795 )

nervous system

abnormal cerebral cortex morphology ( J:136795 )

• at E14.5, mice exhibit abnormal interneuron migration in the cerebral cortex

• the crispness of the boundary between the subventricular zone and the stream of migrating cells is lost

limbs/digits/tail

polydactyly ( J:136795 )

• anterior

Genotype
MGI:3802483

cx2

• Allelic Composition: Pcnt^m275Asp/Pcnt⁺; Tg(Rr291-lacZ)#Mekk/0
• Genetic Background: involves: C57BL/6J * FVB/N

mortality/aging

premature death ( J:136795 )

• mortality among young adults is increased compared to in wild-type mice

nervous system

sporadic seizures ( J:136795 )

behavior/neurological

sporadic seizures ( J:136795 )