About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gabpb1tm1Hhx
targeted mutation 1, Hai-Hui Xue
MGI:3799311
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gabpb1tm1Hhx/Gabpb1tm1Hhx involves: 129 * C57BL/6 MGI:3801697


Genotype
MGI:3801697
hm1
Allelic
Composition		 Gabpb1tm1Hhx/Gabpb1tm1Hhx
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabpb1tm1Hhx mutation (1 available); any Gabpb1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
paraparesis ( J:137300 )
• mice exhibit weak hindlimbs compared to wild-type mice

immune system
immune system phenotype ( J:137300 )
N
• despite the importance of Gabpa for normal immune development and function, both T and B cell development and response to stimuli are normal

muscle
muscle phenotype ( J:137300 )
N
• despite hindlimb weakness, skeletal musculature is normal

nervous system
nervous system phenotype ( J:137300 )
N
• despite hindlimb weakness, the cerebellum, cerebrum, spinal cord and ganglia are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory