Phenotypes associated with this allele

• Allele Symbol: Lpin1^tm1Rchr
• Allele Name: targeted mutation 1, Roman Chrast
• Allele ID: MGI:3799353
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lpin1^tm1Rchr/Lpin1^tm1Rchr Tg(Mpz-cre)26Mes/0	involves: 129S6/SvEvTac * FVB/N	MGI:3800405

Genotype
MGI:3800405

cn1

• Allelic Composition: Lpin1^tm1Rchr/Lpin1^tm1Rchr; Tg(Mpz-cre)26Mes/0
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal Schwann cell morphology ( J:137213 )

• accumulation of myelin debris in Schwann cells, increase in the number of mast cells and defects in unmyelinated Schwann cells

abnormal sciatic nerve morphology ( J:137213 )

• accumulation of lipid-containing particles in the perineurial and endoneurial compartments

• however, unlike Lpin1^fld homozygotes no reduction is seen in the number of adipocytes in the epineurium

demyelination ( J:137213 )

• strong demyelination of the sciatic nerve similar to Lpin1^fld homozygotes

• accumulation of myelin debris in Schwann cells, increase in the number of mast cells and defects in unmyelinated Schwann cells

abnormal nervous system electrophysiology ( J:137213 )

abnormal action potential ( J:137213 )

• reduced motor nerve conduction velocity is accompanied by temporal dispersion and reduction of compound muscle action potentials

decreased nerve conduction velocity ( J:137213 )

• strong reduction in motor nerve conduction velocity of the sciatic nerve at P56

behavior/neurological

limb grasping ( J:137213 )

• clench toes of the hind feet when lifted by the tail

abnormal gait ( J:137213 )

• develops by 2 weeks of age