All Phenotypes Klf3<tm1Merc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Klf3^tm1Merc
targeted mutation 1, Merlin Crossley
MGI:3799368

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klf3^tm1Merc/Klf3^tm1Merc	FVB.129-Klf3^tm1Merc	MGI:3800366
hm2	Klf3^tm1Merc/Klf3^tm1Merc	involves: 129	MGI:5538299
cx3	Klf3^tm1Merc/Klf3^tm1Merc Klf8^{Gt(AD0101)Wtsi}/Klf8^{Gt(AD0101)Wtsi}	involves: 129P2/OlaHsd * FVB/NJ	MGI:5538300
cx4	Klf3^tm1Merc/Klf3^tm1Merc Klf8^{Gt(AD0101)Wtsi}/Klf8⁺	involves: 129P2/OlaHsd * FVB/NJ	MGI:5538301
cx5	Klf3^tm1Merc/Klf3^tm1Merc Klf8^{Gt(AD0101)Wtsi}/Y	involves: 129P2/OlaHsd * FVB/NJ	MGI:5538303

Allelic Composition	Klf3^tm1Merc/Klf3^tm1Merc
Genetic Background	FVB.129-Klf3^tm1Merc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf3^tm1Merc mutation (2 available); any Klf3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:137267 )

• only 17% of mice at weaning are homozygotes instead of the expected 25%

postnatal lethality, incomplete penetrance ( J:137267 )

• expected proportion of homozygotes is found at E14.5 but not at weaning

adipose tissue

decreased total body fat amount ( J:137267 )

• appear leaner

abnormal epididymal fat pad morphology ( J:137267 )

• average cell diameter is about 61% of wild-type and total DNA content is only 56% of wild-type indicating fewer cells are present

abnormal gonadal fat pad morphology ( J:137267 )

• at 12 weeks of age the gonadal fat pad is 38% the size in control littermates

abnormal retroperitoneal fat pad morphology ( J:137267 )

• at 12 weeks of age the retroperitoneal fat pad is 15% the size in control littermates

cellular

abnormal cell differentiation ( J:137267 )

• following exposure to inducers of adipocyte differentiation, MEFs display enhanced lipid accumulation

• however, cell cycle and proliferation are similar to wild-type

growth/size/body

slow postnatal weight gain ( J:137267 )

• similar in size at birth but significantly smaller than littermate controls from 3 to 12 weeks of age

Allelic Composition	Klf3^tm1Merc/Klf3^tm1Merc
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf3^tm1Merc mutation (2 available); any Klf3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:204573 )

• fewer than expected mice are present at weaning

reproductive system

infertility ( J:204573 )

Allelic Composition	Klf3^tm1Merc/Klf3^tm1Merc Klf8^{Gt(AD0101)Wtsi}/Klf8^{Gt(AD0101)Wtsi}
Genetic Background	involves: 129P2/OlaHsd * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf3^tm1Merc mutation (2 available); any Klf3 mutation (80 available)
Klf8^{Gt(AD0101)Wtsi} mutation (1 available); any Klf8 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality during fetal growth through weaning, complete penetrance ( J:204573 )

• no mice are present at weaning

embryonic lethality during organogenesis, incomplete penetrance ( J:204573 )

• most mice die between E12.5 and E14.5

embryo

embryo phenotype ( J:204573 )

N	• mice are largely normal at E13.5

Allelic Composition	Klf3^tm1Merc/Klf3^tm1Merc Klf8^{Gt(AD0101)Wtsi}/Klf8⁺
Genetic Background	involves: 129P2/OlaHsd * FVB/NJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:204573 )

• fewer than expected mice are present at weaning

Allelic Composition	Klf3^tm1Merc/Klf3^tm1Merc Klf8^{Gt(AD0101)Wtsi}/Y
Genetic Background	involves: 129P2/OlaHsd * FVB/NJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality during fetal growth through weaning, complete penetrance ( J:204573 )

• no mice are present at weaning

embryonic lethality during organogenesis, incomplete penetrance ( J:204573 )

• most mice die between E12.5 and E14.5

embryo

embryo phenotype ( J:204573 )

N	• mice are largely normal at E13.5

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