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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CYP19A1-cre)1Jri
transgene insertion 1, JoAnne Richards
MGI:3799733
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0 		involves: 129S4/SvJae MGI:4847591
cn2
 		Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0 		involves: 129S4/SvJae * 129S6/SvEvTac MGI:5784501
cn3
 		Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Tg(CYP19A1-cre)1Jri/0 		involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5432224
cn4
 		Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0 		involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5432226
cn5
 		Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Tg(CYP19A1-cre)1Jri/0 		involves: 129S6/SvEvTac MGI:5784494
cn6
 		Ctnnb1tm1Mmt/Ctnnb1+
Tg(CYP19A1-cre)1Jri/0 		involves: 129X1/SvJ * C57BL/6 MGI:5432223


Genotype
MGI:4847591
cn1
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(CYP19A1-cre)1Jri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased granulosa cell apoptosis ( J:138315 )
• numbers of cleaved caspase 3 (CC3)-positive granulosa cells are decreased in eCG-primed mutant ovaries
impaired luteal cell differentiation ( J:138315 )
• the increased numbers of corpora lutea are at different stages of differentiation than in controls
• steroid biosynthesis is similar in mutants as in controls indicating that even though life span of corpora lutea are extended, they do not remain steroidogenically active
increased granulosa cell proliferation ( J:138315 )
• granulosa cells exhibit increased proliferation
increased corpora lutea number ( J:138315 )
• after 3 months of age, ovaries contain increased numbers of corpora lutea
abnormal ovarian follicle morphology ( J:138315 )
• females exhibit increased follicle growth
• numbers of apoptotic follicles decreased in eCG-primed mutant ovaries
enlarged ovary ( J:138315 )
• after 3 months of age, ovaries are larger and contain increased numbers of corpora lutea

growth/size/body
enlarged ovary ( J:138315 )
• after 3 months of age, ovaries are larger and contain increased numbers of corpora lutea

reproductive system
decreased granulosa cell apoptosis ( J:138315 )
• numbers of cleaved caspase 3 (CC3)-positive granulosa cells are decreased in eCG-primed mutant ovaries
impaired luteal cell differentiation ( J:138315 )
• the increased numbers of corpora lutea are at different stages of differentiation than in controls
• steroid biosynthesis is similar in mutants as in controls indicating that even though life span of corpora lutea are extended, they do not remain steroidogenically active
increased granulosa cell proliferation ( J:138315 )
• granulosa cells exhibit increased proliferation
increased corpora lutea number ( J:138315 )
• after 3 months of age, ovaries contain increased numbers of corpora lutea
abnormal ovarian follicle morphology ( J:138315 )
• females exhibit increased follicle growth
• numbers of apoptotic follicles decreased in eCG-primed mutant ovaries
enlarged ovary ( J:138315 )
• after 3 months of age, ovaries are larger and contain increased numbers of corpora lutea
increased superovulation rate ( J:138315 )
• immature females primed with a superovulatory regiment of equine chorionic gonadotropin (eCG), followed by human CG, ovulate more oocytes than control mice, indicating advanced ovulation rate and increased ovulation
abnormal luteolysis ( J:138315 )
• luteolysis is dramatically impaired and delayed in mutants on a superovulatory regimen of eCG/hCG compared to wild-type mice
enhanced female fertility ( J:138315 )
• females give birth to approximately 20% more pups than controls during a 6-month breeding period

neoplasm
neoplasm ( J:138315 )
N
• females do not develop ovarian tumors

cellular
decreased granulosa cell apoptosis ( J:138315 )
• numbers of cleaved caspase 3 (CC3)-positive granulosa cells are decreased in eCG-primed mutant ovaries
impaired luteal cell differentiation ( J:138315 )
• the increased numbers of corpora lutea are at different stages of differentiation than in controls
• steroid biosynthesis is similar in mutants as in controls indicating that even though life span of corpora lutea are extended, they do not remain steroidogenically active
increased granulosa cell proliferation ( J:138315 )
• granulosa cells exhibit increased proliferation




Genotype
MGI:5784501
cn2
Allelic
Composition		 Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1.1Rdp mutation (0 available); any Foxo1 mutation (32 available)
Foxo1tm1Rdp mutation (2 available); any Foxo1 mutation (32 available)
Foxo3tm1.1Rdp mutation (1 available); any Foxo3 mutation (51 available)
Foxo3tm1Rdp mutation (1 available); any Foxo3 mutation (51 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(CYP19A1-cre)1Jri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased granulosa cell tumor incidence ( J:232961 )
• 60% incidence of granulosa cell tumor occurrence, with early tumor development
• granulosa cell tumors are either solid and surrounded by a thin layer of ovarian tissue containing a few growing follicles or are larger and contain tubular-like structures of different sizes and shapes surrounded by a basal lamina of collagen IV
• mice injected with superovulatory levels of equine gonadotropin and human gonadotropin at 6 weeks of age develop large granulosa cell tumors early

homeostasis/metabolism
abnormal circulating hormone level ( J:232961 )
• tumor bearing mice exhibit increased levels of serum inhibin A and inhibin B
suppressed circulating follicle stimulating hormone level ( J:232961 )
• serum follicle stimulating hormone levels are below the level of detection in tumor bearing mice
decreased circulating luteinizing hormone level ( J:232961 )
• serum luteinizing hormone levels are below the level of detection in tumor bearing mice

neoplasm
increased granulosa cell tumor incidence ( J:232961 )
• 60% incidence of granulosa cell tumor occurrence, with early tumor development
• granulosa cell tumors are either solid and surrounded by a thin layer of ovarian tissue containing a few growing follicles or are larger and contain tubular-like structures of different sizes and shapes surrounded by a basal lamina of collagen IV
• mice injected with superovulatory levels of equine gonadotropin and human gonadotropin at 6 weeks of age develop large granulosa cell tumors early

reproductive system
increased granulosa cell tumor incidence ( J:232961 )
• 60% incidence of granulosa cell tumor occurrence, with early tumor development
• granulosa cell tumors are either solid and surrounded by a thin layer of ovarian tissue containing a few growing follicles or are larger and contain tubular-like structures of different sizes and shapes surrounded by a basal lamina of collagen IV
• mice injected with superovulatory levels of equine gonadotropin and human gonadotropin at 6 weeks of age develop large granulosa cell tumors early




Genotype
MGI:5432224
cn3
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Tg(CYP19A1-cre)1Jri/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(CYP19A1-cre)1Jri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:186144 )
• mutants die within 3.5-5.5 months of age

neoplasm
increased ovary tumor incidence ( J:186144 )
• female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age
increased granulosa cell tumor incidence ( J:186144 )
• female mutants develop bilateral granulosa cell tumors by 3 months of age

endocrine/exocrine glands
impaired granulosa cell differentiation ( J:186144 )
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked
increased ovary tumor incidence ( J:186144 )
• female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age
increased granulosa cell tumor incidence ( J:186144 )
• female mutants develop bilateral granulosa cell tumors by 3 months of age

reproductive system
impaired granulosa cell differentiation ( J:186144 )
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked
increased ovary tumor incidence ( J:186144 )
• female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age
increased granulosa cell tumor incidence ( J:186144 )
• female mutants develop bilateral granulosa cell tumors by 3 months of age

homeostasis/metabolism
decreased circulating estradiol level ( J:186144 )
• at 6 weeks of age in females
increased circulating luteinizing hormone level ( J:186144 )
• at 6 weeks of age in females
decreased circulating progesterone level ( J:186144 )
• at 6 weeks of age in females

cellular
impaired granulosa cell differentiation ( J:186144 )
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
granulosa cell tumor DOID:2999 J:186144
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
 J:186144




Genotype
MGI:5432226
cn4
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(CYP19A1-cre)1Jri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:186144 )
• all mutants die within 2-3 months of age due to tumor burden

neoplasm
increased ovary tumor incidence ( J:186144 )
• mutants exhibit precancerous lesions in the ovaries by 3 weeks of age
increased granulosa cell tumor incidence ( J:186144 )
• mutants develop large granulosa cell tumors by 6-8 weeks of age

endocrine/exocrine glands
decreased granulosa cell apoptosis ( J:186144 )
• granulosa cell apoptosis is decreased in the ovaries at 5-6 weeks of age
impaired granulosa cell differentiation ( J:186144 )
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked
increased granulosa cell proliferation ( J:186144 )
• granulosa cell proliferation is increased in the ovaries at 5-6 weeks of age
increased ovary tumor incidence ( J:186144 )
• mutants exhibit precancerous lesions in the ovaries by 3 weeks of age
increased granulosa cell tumor incidence ( J:186144 )
• mutants develop large granulosa cell tumors by 6-8 weeks of age

reproductive system
decreased granulosa cell apoptosis ( J:186144 )
• granulosa cell apoptosis is decreased in the ovaries at 5-6 weeks of age
impaired granulosa cell differentiation ( J:186144 )
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked
increased granulosa cell proliferation ( J:186144 )
• granulosa cell proliferation is increased in the ovaries at 5-6 weeks of age
increased ovary tumor incidence ( J:186144 )
• mutants exhibit precancerous lesions in the ovaries by 3 weeks of age
increased granulosa cell tumor incidence ( J:186144 )
• mutants develop large granulosa cell tumors by 6-8 weeks of age

homeostasis/metabolism

cellular
decreased granulosa cell apoptosis ( J:186144 )
• granulosa cell apoptosis is decreased in the ovaries at 5-6 weeks of age
impaired granulosa cell differentiation ( J:186144 )
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked
increased granulosa cell proliferation ( J:186144 )
• granulosa cell proliferation is increased in the ovaries at 5-6 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
granulosa cell tumor DOID:2999 J:186144
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
 J:186144




Genotype
MGI:5784494
cn5
Allelic
Composition		 Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Tg(CYP19A1-cre)1Jri/0
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1.1Rdp mutation (0 available); any Foxo1 mutation (32 available)
Foxo1tm1Rdp mutation (2 available); any Foxo1 mutation (32 available)
Foxo3tm1.1Rdp mutation (1 available); any Foxo3 mutation (51 available)
Foxo3tm1Rdp mutation (1 available); any Foxo3 mutation (51 available)
Tg(CYP19A1-cre)1Jri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:232961 )
• 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin exhibit ovaries with many abnormal, degenerating follicles in which oocytes are shrunken or absent
abnormal granulosa cell morphology ( J:232961 )
• in some ovarian follicles of mice injected with superovulatory levels of equine gonadotropin and human gonadotropin, granulosa cells are abnormally displaced and growing on one side
increased granulosa cell tumor incidence ( J:232961 )
• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
• 65% of 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin develop granulosa cell tumors or cysts

homeostasis/metabolism
abnormal circulating hormone level ( J:232961 )
• tumor bearing mice exhibit increased levels of serum inhibin A and inhibin B
increased circulating estradiol level ( J:232961 )
• serum levels of estradiol are elevated in tumor bearing mice
suppressed circulating follicle stimulating hormone level ( J:232961 )
• serum follicle stimulating hormone levels are below the level of detection in tumor bearing mice
decreased circulating luteinizing hormone level ( J:232961 )
• serum luteinizing hormone levels are below the level of detection in tumor bearing mice

neoplasm
increased granulosa cell tumor incidence ( J:232961 )
• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
• 65% of 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin develop granulosa cell tumors or cysts

reproductive system
abnormal ovarian follicle morphology ( J:232961 )
• 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin exhibit ovaries with many abnormal, degenerating follicles in which oocytes are shrunken or absent
abnormal granulosa cell morphology ( J:232961 )
• in some ovarian follicles of mice injected with superovulatory levels of equine gonadotropin and human gonadotropin, granulosa cells are abnormally displaced and growing on one side
increased granulosa cell tumor incidence ( J:232961 )
• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
• 65% of 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin develop granulosa cell tumors or cysts

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
 J:232961




Genotype
MGI:5432223
cn6
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1+
Tg(CYP19A1-cre)1Jri/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(CYP19A1-cre)1Jri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:186144 )
• mutants die within 6-8 months of age

neoplasm
increased ovary tumor incidence ( J:186144 )
• ovaries exhibit visible precancerous lesions between 4 and 6 weeks of age and develop granulosa cell tumors

reproductive system
increased ovary tumor incidence ( J:186144 )
• ovaries exhibit visible precancerous lesions between 4 and 6 weeks of age and develop granulosa cell tumors

endocrine/exocrine glands
increased ovary tumor incidence ( J:186144 )
• ovaries exhibit visible precancerous lesions between 4 and 6 weeks of age and develop granulosa cell tumors

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
 J:186144




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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory