endocrine/exocrine glands
|
• numbers of cleaved caspase 3 (CC3)-positive granulosa cells are decreased in eCG-primed mutant ovaries
|
|
• the increased numbers of corpora lutea are at different stages of differentiation than in controls
• steroid biosynthesis is similar in mutants as in controls indicating that even though life span of corpora lutea are extended, they do not remain steroidogenically active
|
|
• granulosa cells exhibit increased proliferation
|
|
• after 3 months of age, ovaries contain increased numbers of corpora lutea
|
|
• females exhibit increased follicle growth
• numbers of apoptotic follicles decreased in eCG-primed mutant ovaries
|
|
• after 3 months of age, ovaries are larger and contain increased numbers of corpora lutea
|
growth/size/body
|
• after 3 months of age, ovaries are larger and contain increased numbers of corpora lutea
|
reproductive system
|
• numbers of cleaved caspase 3 (CC3)-positive granulosa cells are decreased in eCG-primed mutant ovaries
|
|
• the increased numbers of corpora lutea are at different stages of differentiation than in controls
• steroid biosynthesis is similar in mutants as in controls indicating that even though life span of corpora lutea are extended, they do not remain steroidogenically active
|
|
• granulosa cells exhibit increased proliferation
|
|
• after 3 months of age, ovaries contain increased numbers of corpora lutea
|
|
• females exhibit increased follicle growth
• numbers of apoptotic follicles decreased in eCG-primed mutant ovaries
|
|
• after 3 months of age, ovaries are larger and contain increased numbers of corpora lutea
|
|
• immature females primed with a superovulatory regiment of equine chorionic gonadotropin (eCG), followed by human CG, ovulate more oocytes than control mice, indicating advanced ovulation rate and increased ovulation
|
|
• luteolysis is dramatically impaired and delayed in mutants on a superovulatory regimen of eCG/hCG compared to wild-type mice
|
|
• females give birth to approximately 20% more pups than controls during a 6-month breeding period
|
neoplasm
cellular
|
• numbers of cleaved caspase 3 (CC3)-positive granulosa cells are decreased in eCG-primed mutant ovaries
|
|
• the increased numbers of corpora lutea are at different stages of differentiation than in controls
• steroid biosynthesis is similar in mutants as in controls indicating that even though life span of corpora lutea are extended, they do not remain steroidogenically active
|
|
• granulosa cells exhibit increased proliferation
|