Analysis Tools
mortality/aging
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• all homozygous mice died within 16 days after 7 Gy of irradiation, while 80% of control mice were still alive 2 months after irradiation
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growth/size/body
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• the average weight of 5-month-old homozygous mice was 80% of that of wild-type mice
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cellular
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• fewer spermatocytes were found in seminiferous tubules
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• MEFs from homozygous mutant mice survived less than control MEFs after ionizing irradiation
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• MEFs from homozygous mice grew poorly in vitro due to a decrease in actively dividing cells
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• MEFs from homozygous mutant mice shows severe defects in doubles strand break repair than control MEFs after ionizing irradiation caused DNA damage
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• Cd43+ splenocytes from homozygous mutant mice cultured in presence of concanavalin A for 72 hr shows increased genomic instability, showing increased number of chromosome break, chromatid break, fragmentation, chromosome fusion
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reproductive system
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• fewer spermatocytes were found in seminiferous tubules
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• the diameter of the seminiferous tubules in homozygous mice was smaller than those in wild-type mice
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small testis
(
J:137341
)
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• testes from homozygous mice were only one-fourth the size of those of wild-type mice at the same age
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• homozygous female are fertile, however their litter sizes were smaller than those of wild-type mice
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• homozygous male are infertile due to defective spermatogenesis
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endocrine/exocrine glands
small thymus
(
J:137341
)
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• the thymus derived from homozygous mice are smaller; however, the absolute number of splenic B and T lymphocytes is only modestly reduced
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• the diameter of the seminiferous tubules in homozygous mice was smaller than those in wild-type mice
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small testis
(
J:137341
)
|
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• testes from homozygous mice were only one-fourth the size of those of wild-type mice at the same age
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hematopoietic system
small thymus
(
J:137341
)
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• the thymus derived from homozygous mice are smaller; however, the absolute number of splenic B and T lymphocytes is only modestly reduced
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• a mild defect in Ig class switching
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small spleen
(
J:137341
)
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• the spleen derived from homozygous mice are smaller; however, the absolute number of splenic B and T lymphocytes is only modestly reduced
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immune system
small thymus
(
J:137341
)
|
• the thymus derived from homozygous mice are smaller; however, the absolute number of splenic B and T lymphocytes is only modestly reduced
|
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• a mild defect in Ig class switching
|
small spleen
(
J:137341
)
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• the spleen derived from homozygous mice are smaller; however, the absolute number of splenic B and T lymphocytes is only modestly reduced
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homeostasis/metabolism
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• MEFs from homozygous mutant mice shows severe defects in doubles strand break repair than control MEFs after ionizing irradiation caused DNA damage
|
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• all homozygous mice died within 16 days after 7 Gy of irradiation, while 80% of control mice were still alive 2 months after irradiation
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