Phenotypes associated with this allele

• Allele Symbol: Neto1^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:3799763
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Neto1^tm1(KOMP)Vlcg/Neto1^tm1(KOMP)Vlcg	B6.B6NTac-Neto1^tm1(KOMP)Vlcg	MGI:5140527

Genotype
MGI:5140527

hm1

• Allelic Composition: Neto1^{tm1(KOMP)Vlcg}/Neto1^{tm1(KOMP)Vlcg}
• Genetic Background: B6.B6NTac-Neto1^{tm1(KOMP)Vlcg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synaptic transmission ( J:174015 )

• following a brief bursts of presynaptic stimulation, the charge transfer in CA3 neurons is reduced compared with wild-type cells

• following a burst of presynaptic stimulation with or without pharmacologically isolating kainate receptor excitatory postsynaptic potentiation, CA3 pyramidal cells exhibit a decreased probability of spike after the fifth pulse compared with wild-type cells

• mice exhibit an increase in latency of spikes to the stimulation pulse (jitter) compared with wild-type mice

• however, mice exhibit normal paired-pulse facilitation and long term potentiation

abnormal acid-activated cation-mediated receptor currents ( J:174015 )

• mice exhibit reduced kainate-evoked inward currents in the CA3 pyramidal cells and CA1 interneurons compared with wild-type mice

• however, Purkinje cells exhibit normal kainate-evoked inward currents

abnormal excitatory postsynaptic currents ( J:174015 )

• kainate receptor excitatory postsynaptic current decay kinetics and rise time are faster than in wild-type mice