Phenotypes associated with this allele

• Allele Symbol: Tg(Gfap-Il6)G369Lms
• Allele Name: transgene insertion G369, Lennart Mucke
• Allele ID: MGI:3800178
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Gfap-Il6)G369Lms/Tg(Gfap-Il6)G369Lms	involves: C57BL/6J * SJL	MGI:3804922
tg2	Tg(Gfap-Il6)G369Lms/0	involves: C57BL/6J * SJL	MGI:3804956

Genotype
MGI:3804922

tg1

• Allelic Composition: Tg(Gfap-Il6)G369Lms/Tg(Gfap-Il6)G369Lms
• Genetic Background: involves: C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:137907 )

N • despite neuron loss, no neurofibrillary tangles or plaques are observed

abnormal brain white matter morphology ( J:137907 )

• mice exhibit a loss of white matter axons in the cerebellum

abnormal cerebellar granule cell morphology ( J:137907 )

• mice exhibit a loss of granular neurons in the cerebellum

abnormal astrocyte morphology ( J:137907 )

• mice exhibit spongiform degradation in astrocytes ranging from swelling of astrocytic foot processes to vacuolar changes in the entire cell

gliosis ( J:137907 )

abnormal neuron morphology ( J:137907 )

• mice exhibit neuron loss accompanied by disorganization of remaining neurons with degenerative changes in their axon lengths

abnormal axon morphology ( J:137907 )

• normal axoplasm is replaced with axonal swelling with focal accumulation of organelles and often progresses to collapse of the axon

decreased neuron number ( J:137907 )

decreased Purkinje cell number ( J:137907 )

spongiform encephalopathy ( J:137907 )

• mice exhibit spongiform lesions particularly in the cerebellum where loss of white matter axons, Purkinje cells and granular neurons is observed

• mice exhibit spongiform degradation in astrocytes ranging from swelling of astrocytic foot processes to vacuolar changes in the entire cell

Genotype
MGI:3804956

tg2

• Allelic Composition: Tg(Gfap-Il6)G369Lms/0
• Genetic Background: involves: C57BL/6J * SJL

nervous system

seizures ( J:125549 )

abnormal cerebellar molecular layer ( J:125549 )

• mice exhibit condensation of the molecular layer

• the molecular layer in the cerebellum is atrophic

abnormal astrocyte morphology ( J:125549 )

• astrocytes are hypertrophied with numerous processes

astrocytosis ( J:125549 )

• marked

abnormal dendrite morphology ( J:125549 )

• dendritic processes in the CA1 region of the hippocampus exhibit collapse, vacuolization and reduction in complexity

• Purkinje dendritic processes are tortuous, dilated and exhibit reduced branching

abnormal Purkinje cell dendrite morphology ( J:125549 )

• dendritic processes are tortuous, dilated and exhibit reduced branching

neurodegeneration ( J:125549 )

• neuronal damage

behavior/neurological

abnormal behavior ( J:125549 )

• mice exhibit less severe neurological defects than observed in founder mice

abnormal pilomotor reflex ( J:125549 )

tremors ( J:125549 )

ataxia ( J:125549 )

hunched posture ( J:125549 )

paraparesis ( J:125549 )

• hindlimb weakness

seizures ( J:125549 )

immune system

immune system phenotype ( J:125549 )

N • despite neuronal damage, mice do not exhibit encephalitis or meningitis

cardiovascular system

abnormal physiological neovascularization ( J:125549 )

• marked in the cerebellum

vascular inflammation ( J:125549 )

• mice exhibit descrete perivasculitis in a small number of larger blood vessels in the cerebellar sulci

growth/size/body

decreased body size ( J:125549 )

• at 1 to 2 weeks of age

integument

ruffled hair ( J:125549 )