Phenotypes associated with this allele

• Allele Symbol: Hpcal4^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:3800240
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hpcal4^tm1(KOMP)Vlcg/Hpcal4^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:6401062

Genotype
MGI:6401062

hm1

• Allelic Composition: Hpcal4^{tm1(KOMP)Vlcg}/Hpcal4^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 10300B-C6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:284739 )

N • both sexes exhibit normal baseline withdrawal thresholds in the von Frey test of mechanical pain

N • both sexes show normal nocifensive behaviors (licking/flinching) in response to hindpaw injection of capsaicin or formalin, indicating normal chemical pain responsiveness

N • both sexes show normal mechanical withdrawal thresholds before and after hindpaw injection of Complete Freund's Adjuvant (CFA) or before and after spared nerve injury (SIN), indicating normal tissue and nerve injury-induced mechanical hypersensitivity

N • both sexes exhibit normal levels of scratching bouts in response to peripheral injection of histamine or chloroquine, indicating normal pruritogen responsiveness

increased thermal nociceptive threshold ( J:284739 , J:284739 )

• both sexes exhibit slightly increased paw withdrawal latencies in the Hargreaves test relative to wild-type controls (J:284739)

• however, no behavioral differences are detected in the tail immersion test of heat pain (J:284739)

♂ • male, but not female, mice exhibit higher response latencies at 48 degrees Celsius but not at higher temperatures (J:284739)