All Phenotypes Mcl1<tm1Ywh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mcl1^tm1Ywh
targeted mutation 1, You-Wen He
MGI:3800294

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺ Mcl1^tm1Ywh/Mcl1^tm1Ywh	involves: 129/Sv * 129S6/SvEvTac * C57BL/6	MGI:3801467
cn2	Mcl1^tm1Ywh/Mcl1^tm1Ywh Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:3801426
cn3	Mcl1^tm1Ywh/Mcl1^tm1Ywh Tg(Lck-cre)548Jxm/0	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA	MGI:3801464
cn4	Mcl1^tm1Ywh/Mcl1^tm1Ywh Tg(Cd4-cre)1Cwi/0	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:3801466
cn5	Bcl2l1^tm1Ywh/Bcl2l1^tm1Ywh Mcl1^tm1Ywh/Mcl1^tm1Ywh Tg(Cd4-cre)1Cwi/0	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:3801468

Allelic Composition	Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺ Mcl1^tm1Ywh/Mcl1^tm1Ywh
Genetic Background	involves: 129/Sv * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Mcl1^tm1Ywh mutation (0 available); any Mcl1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell apoptosis ( J:137400 )

• in culture following treatment with tamoxifen regardless of activation status T cell survival is decreased comapred to similarly treated wild-type cells

cellular

increased T cell apoptosis ( J:137400 )

• in culture following treatment with tamoxifen regardless of activation status T cell survival is decreased comapred to similarly treated wild-type cells

hematopoietic system

increased T cell apoptosis ( J:137400 )

• in culture following treatment with tamoxifen regardless of activation status T cell survival is decreased comapred to similarly treated wild-type cells

Allelic Composition	Mcl1^tm1Ywh/Mcl1^tm1Ywh Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Mcl1^tm1Ywh mutation (0 available); any Mcl1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:137502 )

N	• despite reduced neutrophil numbers and recruitment, the number of monocytes, recruitment of macrophages during peritonitis and macrophage survival and cytokine production after Toll-like receptor stimulation are normal

increased eosinophil cell number ( J:137502 )

• in the blood, spleen and bone marrow

decreased granulocyte number ( J:137502 )

• the number of Mac-1+Gr1+ granulocytes is decreased in the bone marrow as well as decreased 80% in peripheral blood and 86% in spleen compared to in wild-type mice

decreased neutrophil cell number ( J:137502 )

• the number of neutrophils is reduced by 80% compared to in wild-type mice due to increased apoptosis of neutrophils

• however, mice that do not exhibit proper cre-mediated deletion survive

abnormal neutrophil physiology ( J:137502 )

• apoptosis of neutrophils is enhanced

• however, mice that do not exhibit proper cre-mediated deletion survive

impaired neutrophil recruitment ( J:137502 )

• mice exhibit an 80% decrease in neutrophils recruited to peritoneal cells treated with thioglycollate to induce peritonitis compared to similarly treated wild-type mice

hematopoietic system

increased eosinophil cell number ( J:137502 )

• in the blood, spleen and bone marrow

decreased granulocyte number ( J:137502 )

• the number of Mac-1+Gr1+ granulocytes is decreased in the bone marrow as well as decreased 80% in peripheral blood and 86% in spleen compared to in wild-type mice

decreased neutrophil cell number ( J:137502 )

• the number of neutrophils is reduced by 80% compared to in wild-type mice due to increased apoptosis of neutrophils

• however, mice that do not exhibit proper cre-mediated deletion survive

abnormal neutrophil physiology ( J:137502 )

• apoptosis of neutrophils is enhanced

• however, mice that do not exhibit proper cre-mediated deletion survive

impaired neutrophil recruitment ( J:137502 )

• mice exhibit an 80% decrease in neutrophils recruited to peritoneal cells treated with thioglycollate to induce peritonitis compared to similarly treated wild-type mice

Allelic Composition	Mcl1^tm1Ywh/Mcl1^tm1Ywh Tg(Lck-cre)548Jxm/0
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1^tm1Ywh mutation (0 available); any Mcl1 mutation (35 available)
Tg(Lck-cre)548Jxm mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell apoptosis ( J:137400 )

• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice

thymus hypoplasia ( J:137400 )

• thymus contain 5% of the cells found in wild-type mice

abnormal T cell differentiation ( J:137400 )

• T cell development is blocked between DN2/3 and DN4 stages

• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice

decreased double-negative T cell number ( J:137400 )

• 5% to 10% of wild-type

decreased double-positive T cell number ( J:137400 )

• 40% of wild-type

decreased T cell number ( J:137400 )

• T cell numbers in the spleen are 40% to 50% of wild-type

decreased CD4-positive, alpha-beta T cell number ( J:137400 )

• 5% to 10% of wild-type

decreased CD8-positive, alpha-beta T cell number ( J:137400 )

• 5% to 10% of wild-type

hematopoietic system

increased T cell apoptosis ( J:137400 )

• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice

thymus hypoplasia ( J:137400 )

• thymus contain 5% of the cells found in wild-type mice

abnormal T cell differentiation ( J:137400 )

• T cell development is blocked between DN2/3 and DN4 stages

• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice

decreased T cell number ( J:137400 )

• T cell numbers in the spleen are 40% to 50% of wild-type

decreased double-negative T cell number ( J:137400 )

• 5% to 10% of wild-type

decreased double-positive T cell number ( J:137400 )

• 40% of wild-type

decreased CD4-positive, alpha-beta T cell number ( J:137400 )

• 5% to 10% of wild-type

decreased CD8-positive, alpha-beta T cell number ( J:137400 )

• 5% to 10% of wild-type

cellular

increased T cell apoptosis ( J:137400 )

• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice

endocrine/exocrine glands

thymus hypoplasia ( J:137400 )

• thymus contain 5% of the cells found in wild-type mice

Allelic Composition	Mcl1^tm1Ywh/Mcl1^tm1Ywh Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1^tm1Ywh mutation (0 available); any Mcl1 mutation (35 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell apoptosis ( J:137400 )

• the number of mature T cells in the spleen is less than 10% of wild-type

increased double-positive T cell number ( J:137400 )

• slight increase in the frequency

decreased T cell number ( J:137400 )

• the number of mature T cells in the spleen is less than 10% of wild-type

decreased CD4-positive, alpha-beta T cell number ( J:137400 )

• the frequency of total CD4+ thymocytes and mature CD4+ thymocytes is decreased compared to in wild-type mice

• few CD4+ T cells are detected

decreased CD8-positive, alpha-beta T cell number ( J:137400 )

• the frequency of CD8+ T cells is reduced by greater than 80% compared to in wild-type mice

• the frequency of mature CD8+ thymocytes is reduced over 10-fold compared to in wild-type mice

• few CD8+ T cells are detected

hematopoietic system

increased T cell apoptosis ( J:137400 )

• the number of mature T cells in the spleen is less than 10% of wild-type

increased double-positive T cell number ( J:137400 )

• slight increase in the frequency

decreased T cell number ( J:137400 )

• the number of mature T cells in the spleen is less than 10% of wild-type

decreased CD4-positive, alpha-beta T cell number ( J:137400 )

• the frequency of total CD4+ thymocytes and mature CD4+ thymocytes is decreased compared to in wild-type mice

• few CD4+ T cells are detected

decreased CD8-positive, alpha-beta T cell number ( J:137400 )

• the frequency of CD8+ T cells is reduced by greater than 80% compared to in wild-type mice

• the frequency of mature CD8+ thymocytes is reduced over 10-fold compared to in wild-type mice

• few CD8+ T cells are detected

cellular

increased T cell apoptosis ( J:137400 )

• the number of mature T cells in the spleen is less than 10% of wild-type

Allelic Composition	Bcl2l1^tm1Ywh/Bcl2l1^tm1Ywh Mcl1^tm1Ywh/Mcl1^tm1Ywh Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1^tm1Ywh mutation (0 available); any Bcl2l1 mutation (104 available)
Mcl1^tm1Ywh mutation (0 available); any Mcl1 mutation (35 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased double-positive T cell number ( J:137400 )

• the frequency of double positive T cells is reduced to 45% of thymocytes compared to 85% in wild-type mice

• the absolute number of double positive cells is 10% of wild-type

absent CD4-positive, alpha-beta T cells ( J:137400 )

absent CD8-positive, alpha-beta T cells ( J:137400 )

hematopoietic system

decreased double-positive T cell number ( J:137400 )

• the frequency of double positive T cells is reduced to 45% of thymocytes compared to 85% in wild-type mice

• the absolute number of double positive cells is 10% of wild-type

absent CD4-positive, alpha-beta T cells ( J:137400 )

absent CD8-positive, alpha-beta T cells ( J:137400 )

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