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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2l11tm3Rjd
targeted mutation 3, Roger J Davis
MGI:3800462
Summary 2 genotypes


Genotype
MGI:3800465
hm1
Allelic
Composition		 Bcl2l11tm3Rjd/Bcl2l11tm3Rjd
Genetic
Background		 B6.129S6-Bcl2l11tm3Rjd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3Rjd mutation (1 available); any Bcl2l11 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased thymocyte apoptosis ( J:137061 )
• reduced apoptosis of autoreactive DP thymocytes
• homozygous mutants were born from heterozygous crosses, the average litter size obtained from matings of homozygous mutant mice was normal

hematopoietic system
decreased thymocyte apoptosis ( J:137061 )
• reduced apoptosis of autoreactive DP thymocytes
• homozygous mutants were born from heterozygous crosses, the average litter size obtained from matings of homozygous mutant mice was normal
increased B cell number ( J:153652 )
• a moderate increase in the number of B cells in the spleen
increased CD4-positive, alpha-beta T cell number ( J:153652 )
• a moderate increase in the number of CD4-positive T cells in the spleen
increased CD8-positive, alpha-beta T cell number ( J:153652 )
• a moderate increase in the number of CD8-positive T cells in the spleen
increased splenocyte number ( J:153652 )
• increased number of splenocytes (about 1.5 fold)

immune system
decreased thymocyte apoptosis ( J:137061 )
• reduced apoptosis of autoreactive DP thymocytes
• homozygous mutants were born from heterozygous crosses, the average litter size obtained from matings of homozygous mutant mice was normal
increased B cell number ( J:153652 )
• a moderate increase in the number of B cells in the spleen
increased CD4-positive, alpha-beta T cell number ( J:153652 )
• a moderate increase in the number of CD4-positive T cells in the spleen
increased CD8-positive, alpha-beta T cell number ( J:153652 )
• a moderate increase in the number of CD8-positive T cells in the spleen
increased splenocyte number ( J:153652 )
• increased number of splenocytes (about 1.5 fold)

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:137061 )
• reduced apoptosis of autoreactive DP thymocytes
• homozygous mutants were born from heterozygous crosses, the average litter size obtained from matings of homozygous mutant mice was normal




Genotype
MGI:4421204
cx2
Allelic
Composition		 Bcl2l11tm3Rjd/Bcl2l11tm3Rjd
Bmftm3.1Rjd/Bmftm3.1Rjd
Genetic
Background		 B6.129S6-Bcl2l11tm3Rjd Bmftm3.1Rjd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3Rjd mutation (1 available); any Bcl2l11 mutation (36 available)
Bmftm3.1Rjd mutation (1 available); any Bmf mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell number ( J:153652 )
• a moderate increase in the number of B cells in the spleen
increased CD4-positive, alpha-beta T cell number ( J:153652 )
• a moderate increase in the number of CD4-positive T cells in the spleen
increased CD8-positive, alpha-beta T cell number ( J:153652 )
• a moderate increase in the number of CD8-positive T cells in the spleen
increased splenocyte number ( J:153652 )
• increased number of splenocytes (about 1.5 fold)

immune system
increased B cell number ( J:153652 )
• a moderate increase in the number of B cells in the spleen
increased CD4-positive, alpha-beta T cell number ( J:153652 )
• a moderate increase in the number of CD4-positive T cells in the spleen
increased CD8-positive, alpha-beta T cell number ( J:153652 )
• a moderate increase in the number of CD8-positive T cells in the spleen
increased splenocyte number ( J:153652 )
• increased number of splenocytes (about 1.5 fold)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory