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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2l11tm4Rjd
targeted mutation 4, Roger J Davis
MGI:3800472
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl2l11tm4Rjd/Bcl2l11tm4Rjd B6.129S6-Bcl2l11tm4Rjd MGI:3800474
hm2
 		Bcl2l11tm4Rjd/Bcl2l11tm4Rjd involves: 129S6/SvEvTac * C57BL/6 MGI:5527380


Genotype
MGI:3800474
hm1
Allelic
Composition		 Bcl2l11tm4Rjd/Bcl2l11tm4Rjd
Genetic
Background		 B6.129S6-Bcl2l11tm4Rjd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm4Rjd mutation (1 available); any Bcl2l11 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased fibroblast apoptosis ( J:137061 )
• increased serum withdrawal induced apoptosis of MEF cells in culture
• homozygous mutants were born from heterozygous crosses, the average litter size obtained from matings of homozygous mutant mice was normal




Genotype
MGI:5527380
hm2
Allelic
Composition		 Bcl2l11tm4Rjd/Bcl2l11tm4Rjd
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm4Rjd mutation (1 available); any Bcl2l11 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:203181 )
N
• normal numbers of white blood cells, splenocytes, thymocytes, lymphocytes, neutrophils, platelets, B cells and T cells

immune system
immune system phenotype ( J:203181 )
N
• normal numbers of white blood cells, splenocytes, thymocytes, lymphocytes, neutrophils, platelets, B cells and T cells
• double positive thymocytes exhibit normal sensitivity to apoptotic stimuli
• mice exhibit normal mitogenic activation of T and B cells




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory