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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Arsbm1J
mutation 1, Jackson
MGI:3800577
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Arsbm1J/Arsbm1J C57BL/6J-Arsbm1J/GrsrJ MGI:3849442


Genotype
MGI:3849442
hm1
Allelic
Composition
Arsbm1J/Arsbm1J
Genetic
Background
C57BL/6J-Arsbm1J/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arsbm1J mutation (1 available); any Arsb mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Arsbm1J/Arsbm1J mice (left) exhibit a shortened snout, wide-set eyes and shortened limbs

behavior/neurological

craniofacial

vision/eye

limbs/digits/tail
• thicker digits
• shortened limbs become more noticeable with age

adipose tissue

growth/size/body

skeleton
• greater whole body bone mineral density

hearing/vestibular/ear
• ABR indicative of severe hearing loss

reproductive system
• although both females and males reproduce, small litters and poor breeding have occurred

muscle
• focal muscle degeneration is found in an 8 month old

nervous system
• an 8 month old homozygote shows peripheral nerve degeneration with macrophage infiltration and a 14 month old shows peripheral nerve degeneration with spinal arthritis and vacuoles in the connective tissue around the spine

cellular

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
mucopolysaccharidosis VI DOID:12800 OMIM:253200
J:149960





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory