growth/size/body
• at three weeks of age, homozygous mutant mice are significantly smaller than their littermates
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behavior/neurological
• mutant mice, some as young as 3 months of age, develop a hunched posture
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• the tremor is often accompanied by stiff and deliberate hindfoot placement during locomotion, particularly in older mutants
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• although both male and female homozygotes are fertile, mutant males do not breed
• homozygous mutant females are able to breed
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integument
• the coats of mutant mice, some as young as 3 months of age, become dull and lack-luster
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