All Phenotypes Mecp2<tm1Pplt> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mecp2^tm1Pplt/Mecp2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3801488
ot2	Mecp2^tm1Pplt/Y	involves: 129S1/Sv * 129X1/SvJ	MGI:3801486
ot3	Mecp2^tm1Pplt/Y	involves: 129S1/Sv * 129X1/SvJ * C3H/HeSn	MGI:3801485
ot4	Mecp2^tm1Pplt/Y	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3801487
ot5	Mecp2^tm1Pplt/0	involves: 129S1/Sv * 129X1/SvJ * C3H/HeSn	MGI:3801484

Allelic Composition	Mecp2^tm1Pplt/Mecp2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Pplt mutation (0 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:137344 )

• motor defect on initial exposure to rotarod test

• rotarod performance normalized when maintained in an "enriched" environment

• rotarod performance improves over 5 days of training

• rotarod performance remains deficient relative to wild-type kept in a standard environment

• coordination improvement acquired with training is lost in the weeks subsequent to training

• "enriched" environment prevents coordination deficiency from developing

decreased vertical activity ( J:137344 )

• reduced rearing activity regardless of the environment

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:137344

Allelic Composition	Mecp2^tm1Pplt/Y
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Pplt mutation (0 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:137513 )

• dead by 5 weeks

Allelic Composition	Mecp2^tm1Pplt/Y
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeSn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Pplt mutation (0 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:137513 )

• these mice retain the neo insert in the Mecp2^tm1Pplt allele

• 50% dead by 7 weeks

growth/size/body

malocclusion ( J:137513 )

• these mice retain the neo insert in the Mecp2^tm1Pplt allele

• reported for this background

weight loss ( J:137513 )

• these mice retain the neo insert in the Mecp2^tm1Pplt allele

• progressive weight loss after 11 weeks of age

postnatal growth retardation ( J:137513 )

• these mice retain the neo insert in the Mecp2^tm1Pplt allele

• growth normal until 5 weeks of age

• growth retardation after 5 weeks

behavior/neurological

lethargy ( J:137513 )

• these mice retain the neo insert in the Mecp2^tm1Pplt allele

• accompanies weight loss

craniofacial

malocclusion ( J:137513 )

• these mice retain the neo insert in the Mecp2^tm1Pplt allele

• reported for this background

skeleton

malocclusion ( J:137513 )

• these mice retain the neo insert in the Mecp2^tm1Pplt allele

• reported for this background

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:137513 )

• 50% lethality by 8 weeks

growth/size/body

weight loss ( J:137513 )

• marked weight loss starting about 1 week before death

postnatal growth retardation ( J:137513 )

• failure to thrive after 5 weeks

• mean weight 15 g at 8 weeks comppared to 21 g for controls

behavior/neurological

behavior/neurological phenotype ( J:137344 )

N	• general locomotion is normal through 6 weeks of age

abnormal associative learning ( J:137513 )

abnormal contextual conditioning behavior ( J:137513 )

• reduced ability to associate foot shock with context

abnormal cued conditioning behavior ( J:137513 )

• reduced ability to associate auditory cue to footshock

abnormal fear/anxiety-related behavior ( J:137513 )

decreased anxiety-related response ( J:137513 )

• as measured on an elevated + maze

abnormal motor capabilities/coordination/movement ( J:137513 )

limb grasping ( J:137513 )

• clasping of hind limbs when lifted by the tail

tremors ( J:137513 )

impaired coordination ( J:137344 , J:137513 )

• coordination remains impaired through week 9 (J:137344)

• time spent on an accelerating rotarod about 1/3 that of controls (J:137513)

• no improvement with successive trials (J:137513)

abnormal locomotor behavior ( J:137513 )

abnormal gait ( J:137513 )

• splayed limbs

decreased vertical activity ( J:137344 )

• less rearing behavior when maintained in a standard environment

decreased locomotor activity ( J:137513 )

• lower activity levels on free wheels in mice before onset of breathing problems or seizures

sporadic seizures ( J:137513 )

• episodes of seizures

nervous system

sporadic seizures ( J:137513 )

• episodes of seizures

decreased brain weight ( J:137513 )

respiratory system

respiratory distress ( J:137513 )

• labored breathing

integument

disheveled coat ( J:137513 )

abnormal vibrissa morphology ( J:137513 )

• erect whiskers

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:137344

Allelic Composition	Mecp2^tm1Pplt/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeSn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Pplt mutation (0 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:137513 )

• these mice retain the neo insert in the Mecp2^tm1Pplt allele

• 50% dead by 7 weeks

growth/size/body

malocclusion ( J:137513 )

• these mice retain the neo insert in the Mecp2^tm1Pplt allele

• reported for this background

weight loss ( J:137513 )

• these mice retain the neo insert in the Mecp2^tm1Pplt allele

• progressive weight loss after 11 weeks of age

postnatal growth retardation ( J:137513 )

• these mice retain the neo insert in the Mecp2^tm1Pplt allele

• growth normal for first 6-7 weeks of life

• growth retardation after 7 weeks

behavior/neurological

lethargy ( J:137513 )

• these mice retain the neo insert in the Mecp2^tm1Pplt allele

• accompanies weight loss

craniofacial

malocclusion ( J:137513 )

• these mice retain the neo insert in the Mecp2^tm1Pplt allele

• reported for this background

skeleton

malocclusion ( J:137513 )

• these mice retain the neo insert in the Mecp2^tm1Pplt allele

• reported for this background

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