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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zap70m6Hefl
mutation 6, Heinrich Flaswinkel
MGI:3800788
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zap70m6Hefl/Zap70m6Hefl C3HeB/FeJ-Zap70m6Hefl MGI:3802704
ht2
 		Zap70m6Hefl/Zap70tm1Weis involves: 129X1/SvJ * C3HeB/FeJ * C57BL/10 * DBA/2 MGI:3802707


Genotype
MGI:3802704
hm1
Allelic
Composition		 Zap70m6Hefl/Zap70m6Hefl
Genetic
Background		 C3HeB/FeJ-Zap70m6Hefl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70m6Hefl mutation (0 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:137446 )
N
• despite the reduction in CD3+ T cells, total leukocyte and lymphocyte counts are normal and mice do not exhibit hypogammaglobulinemia
abnormal T cell differentiation ( J:137446 )
• mice exhibit an almost complete block in thymocyte development at the transition from CD4+CD8+ double positive to CD4+ or CD8+ single-positive T cells
decreased T cell number ( J:137446 )
• peripheral CD3+ T cells are almost completely absent
abnormal humoral immune response ( J:137446 )
• mice fail to mount a humoral immune response when stimulated
increased IgE level ( J:137446 )
• up to 100-fold

hematopoietic system
abnormal T cell differentiation ( J:137446 )
• mice exhibit an almost complete block in thymocyte development at the transition from CD4+CD8+ double positive to CD4+ or CD8+ single-positive T cells
decreased T cell number ( J:137446 )
• peripheral CD3+ T cells are almost completely absent
increased IgE level ( J:137446 )
• up to 100-fold




Genotype
MGI:3802707
ht2
Allelic
Composition		 Zap70m6Hefl/Zap70tm1Weis
Genetic
Background		 involves: 129X1/SvJ * C3HeB/FeJ * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70m6Hefl mutation (0 available); any Zap70 mutation (55 available)
Zap70tm1Weis mutation (2 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell number ( J:137446 )
• peripheral T cells are dramatically reduced compared to in wild-type mice

immune system
decreased T cell number ( J:137446 )
• peripheral T cells are dramatically reduced compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory