Analysis Tools
mortality/aging
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• 30% of mice survive beyond P120
• fewer mice die when over-expression begins at P60 instead of P40
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• most mice die before 3 months of age frequently between P25 and P80
• in 37% of mice, crises of severe bradycardia and hypothermia progress to death
• however, 30% of mice survive beyond P120 and treatment with doxycycline prevents premature death
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nervous system
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• mice exhibit sporadic autonomic crisis, involving bradycardia preceded 5 to 10 minutes by hypothermia, that persists for several hours and is followed by several days of recovery or, in the case of 37% of mice, progresses to death
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• following treatment of brain slices with tryptophan, cells exhibit reduced firing compared to wild-type cells
• however, normal cell firing can be re-established by treatment with doxycycline
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cardiovascular system
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• mice exhibit sporadic autonomic crises involving a decrease in heart rate and temperature than persists for several hours followed by several days of recovery
• bradycardia precedes hypothermia by 5 to 10 minutes
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homeostasis/metabolism
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• mice exhibit sporadic autonomic crises involving a decrease in heart rate and temperature than persists for several hours followed by several days of recovery
• bradycardia precedes hypothermia by 5 to 10 minutes
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