Phenotypes associated with this allele

• Allele Symbol: Fmn1^tm1Awb
• Allele Name: targeted mutation 1, Anthony Wynshaw-Boris
• Allele ID: MGI:3800994
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fmn1^tm1Awb/Fmn1^tm1Awb	involves: 129S4/SvJae	MGI:3800997
hm2	Fmn1^tm1Awb/Fmn1^tm1Awb	involves: 129S4/SvJae * NIH Black Swiss	MGI:3800998
ht3	Fmn1^tm1Awb/Fmn1^ld-Is(17;In2)1Gso	involves: 101/Rl * 129S4/SvJae * C3H/Rl * NIH Black Swiss	MGI:3801003
ht4	Fmn1^tm1Awb/Fmn1^ld-TgBri137	involves: 129S4/SvJae * C57BL/6 * NIH Black Swiss * SJL	MGI:3801001

Genotype
MGI:3800997

hm1

• Allelic Composition: Fmn1^tm1Awb/Fmn1^tm1Awb
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:137209 )

• protrusion and retraction rates are increased and the persistence of protrusive activity and length of protrusions are decreased in MEFs

• plated MEFs show a significant reduction in focal adhesion area

Genotype
MGI:3800998

hm2

• Allelic Composition: Fmn1^tm1Awb/Fmn1^tm1Awb
• Genetic Background: involves: 129S4/SvJae * NIH Black Swiss

renal/urinary system

absent kidney ( J:43337 )

• a small percentage of mice display bilateral renal agenesis

single kidney ( J:43337 )

• a small percentage of mice display unilateral renal agenesis

absent ureter ( J:43337 )

• in some cases of renal agenesis, the ureters on the ipsilateral side were absent

blind ureter ( J:43337 )

• in some cases of renal agenesis, blind-ended ureters originating from the bladder were present

limbs/digits/tail

limbs/digits/tail phenotype ( J:43337 )

N • unlike mice homozygous for other Fmn1 alleles no limb deformities are detected

Genotype
MGI:3801003

ht3

• Allelic Composition: Fmn1^tm1Awb/Fmn1^{ld-Is(17;In2)1Gso}
• Genetic Background: involves: 101/Rl * 129S4/SvJae * C3H/Rl * NIH Black Swiss

renal/urinary system

polycystic kidney ( J:43337 )

• a small percentage of mice display bilateral multicystic dysplastic kidneys

limbs/digits/tail

limbs/digits/tail phenotype ( J:43337 )

N • unlike mice homozygous for Fmn1^{ld-Is(17;In2)1Gso} no limb deformities are detected

growth/size/body

polycystic kidney ( J:43337 )

• a small percentage of mice display bilateral multicystic dysplastic kidneys

Genotype
MGI:3801001

ht4

• Allelic Composition: Fmn1^tm1Awb/Fmn1^ld-TgBri137
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * NIH Black Swiss * SJL

renal/urinary system

single kidney ( J:43337 )

• a small percentage of mice display unilateral renal agenesis

limbs/digits/tail

limbs/digits/tail phenotype ( J:43337 )

N • unlike mice homozygous for Fmn1^ld-TgBri137 no limb deformities are detected