Phenotypes associated with this allele

• Allele Symbol: Ifih1^tm1Aki
• Allele Name: targeted mutation 1, Shizuro Akira
• Allele ID: MGI:3801032
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifih1^tm1Aki/Ifih1^tm1Aki	involves: 129/Sv * C57BL/6	MGI:3803342
cx2	Ifih1^tm1Aki/Ifih1^tm1Aki Ticam1^tm1Aki/Ticam1^tm1Aki	involves: 129P2/OlaHsd	MGI:3803346
cx3	Rigi^tm1Aki/Rigi^tm1Aki Ifih1^tm1Aki/Ifih1^tm1Aki	involves: 129/Sv * C57BL/6	MGI:3803343

Genotype
MGI:3803342

hm1

• Allelic Composition: Ifih1^tm1Aki/Ifih1^tm1Aki
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal interferon level ( J:137522 )

• fail to produce interferon alpha and interferon beta in response to poly(I:C)

abnormal interleukin level ( J:137522 )

• impaired production of IL6 and IL12p40 in response to poly(I:C)

abnormal dendritic cell physiology ( J:137522 )

• severely impaired production of interferon alpha and interferon beta in bone marrow derived dendritic cells stimulated with poly(I:C)

• impaired production of interferon beta and IL6 in response to encephalomyocarditis virus (positive sense ssRNA virus) in bone marrow derived dendritic cells

increased susceptibility to Picornaviridae infection ( J:137522 )

• increased susceptibility of encephalomyocarditis virus induced lethality

• but susceptibility to Japanese encephalitis virus and vesicular stomatitis virus is similar to controls

cellular

abnormal cell physiology ( J:137522 )

• impaired production of interferon beta in MEFs stimulated with poly(I:C), encephalomyocarditis virus (positive sense ssRNA virus)

• however, production of interferon beta in response to dsRNA and production of type-I interferons in response to mutant negative-sense ssRNA viruses are similar to controls

homeostasis/metabolism

abnormal interferon level ( J:137522 )

• fail to produce interferon alpha and interferon beta in response to poly(I:C)

abnormal interleukin level ( J:137522 )

• impaired production of IL6 and IL12p40 in response to poly(I:C)

Genotype
MGI:3803346

cx2

• Allelic Composition: Ifih1^tm1Aki/Ifih1^tm1Aki; Ticam1^tm1Aki/Ticam1^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd

immune system

abnormal interferon level ( J:137522 )

• fail to produce interferon alpha in response to poly(I:C)

abnormal interleukin level ( J:137522 )

• fail to produce IL6 and IL12p40 in response to poly(I:C)

homeostasis/metabolism

abnormal interferon level ( J:137522 )

• fail to produce interferon alpha in response to poly(I:C)

abnormal interleukin level ( J:137522 )

• fail to produce IL6 and IL12p40 in response to poly(I:C)

Genotype
MGI:3803343

cx3

• Allelic Composition: Rigi^tm1Aki/Rigi^tm1Aki; Ifih1^tm1Aki/Ifih1^tm1Aki
• Genetic Background: involves: 129/Sv * C57BL/6

cellular

abnormal cell physiology ( J:137522 )

• complete loss of interferon beta production in response to Sendai virus (with a mutated C protein) or encephalomyocarditis virus