Analysis Tools|
Allele Symbol Allele Name Allele ID |
Droshatm1Litt targeted mutation 1, Dan R Littman MGI:3801076 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• naive CD4+ T cells release more interferon gamma than controls after cre-mediated deletion of Rnasen induced by tamoxifen treatment
• deficient CD4+ T cells are capable of differentiating into Th1 or Th2 cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal kidney size with fully developed glomeruli
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• protein deposits in kidney tubules by age P28
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• protein deposits in kidney tubules by age P28
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| N |
• viable; live to at least 6 months
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cachexic animals become moribund rapidly and are euthanized; by 6 months, 50% mortality in mutants is observed
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• moribund animals show complete loss of visceral adipose tissue
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| N |
• spleen and lymph nodes are not larger than controls despite T cell abnormalities
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• higher frequency of granulocytes in spleen and lymph nodes is observed
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• increase is detected in spleen and lymph nodes
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• significant increase in frequency of activated (CD62Llo44hi) CD4+ T cells is observed in spleen and lymph nodes
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• T lymphopenia in CD8+ compartment is observed
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• total thymocyte number is decreased compared to controls at 6 weeks; reduced frequency of TCRbeta+ thymocytes with downregulated CD14 and CD69 is observed
• absolute number of mature thymocytes is significantly reduced
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• absolute number of double positive (DP) thymocytes is significantly reduced compared to controls at 6 weeks
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• significant reduction in frequency of mature CD8+ T cells is observed in periphery at 6 weeks
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• mature peripheral T reg cells are reduced in frequency
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• very high frequencies of interferon gamma- or IL-17A-secreting cells are observed; high frequency of interferon gamma/IL-17A double secreting cells is detected in moribund animals
• slight increase in frequency of interferon gamma- or IL-17A-secreting CD4+ T cells can be seen at 3 months
• regulatory T cells have reduced suppressive activity compared to controls; in vitro proliferation of stimulated CD25-CD4+ T cells is only partially suppressed
• deficient CD4+ T cells are capable of differentiating into Th1 or Th2 cells
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• small foci of inflammatory cells are more prevalent than in controls
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• infiltrating cells accumulate around most blood vessels in liver with additional foci in sinusoids
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• infiltrating cells accumulate primarily around blood vessels, resulting in epithelial thickening of surrounding tissue
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• higher frequency of granulocytes in spleen and lymph nodes is observed
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• increase is detected in spleen and lymph nodes
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• significant increase in frequency of activated (CD62Llo44hi) CD4+ T cells is observed in spleen and lymph nodes
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• T lymphopenia in CD8+ compartment is observed
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• total thymocyte number is decreased compared to controls at 6 weeks; reduced frequency of TCRbeta+ thymocytes with downregulated CD14 and CD69 is observed
• absolute number of mature thymocytes is significantly reduced
|
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• absolute number of double positive (DP) thymocytes is significantly reduced compared to controls at 6 weeks
|
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• significant reduction in frequency of mature CD8+ T cells is observed in periphery at 6 weeks
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• mature peripheral T reg cells are reduced in frequency
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• moribund animals show complete loss of visceral adipose tissue
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• infiltrating cells accumulate around most blood vessels in liver with additional foci in sinusoids
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• infiltrating cells accumulate primarily around blood vessels, resulting in epithelial thickening of surrounding tissue
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• moribund animals exhibit reduction in muscle mass
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• small foci of inflammatory cells are more prevalent than in controls
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• total thymocyte number is decreased compared to controls at 6 weeks; reduced frequency of TCRbeta+ thymocytes with downregulated CD14 and CD69 is observed
• absolute number of mature thymocytes is significantly reduced
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• doxycycline-treated mice retain hair follicle stem cells in early telogen and anagen
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• hair phenotype in doxycycline-treated mice appears more slowly than in Dicer1tm1Smr/Dicer1tm1Smr Tg(KRT5-rtTA)1Glk Tg(tetO-cre)1Jaw mice
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• failure of hair regrowth in doxycycline-treated mice
• failure of regression at P20 in doxycycline-treated mice and remained in an abnormal growth phase
• following hair plucking, doxycycline-treated mice fail to sustain hair growth unlike control mice
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• external hair becomes wavy between P12 and P14 in doxycycline-treated mice
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• in doxycycline-treated mice likely due to matrix cell apoptosis
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• at P17 in doxycycline-treated mice after degradation begins
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• fewer differentiation cell in doxycycline-treated mice following plucking-induced anagen initiation
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• with extrusion of abnormally keratinized cellular material in doxycycline-treated mice
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• in doxycycline-treated mice following plucking-induced anagen initiation
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• failure of catagen in doxycycline-treated mice
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• failure of regression at P20 in doxycycline-treated mice
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• by P20, doxycycline-treated mice exhibit thickened interfollicular epidermis compared with control mice
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• mice treated with doxycycline exhibit a temporary phenotype of dry scaly skin that is resolved in an anterior-posterior direction
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• mice treated with doxycycline exhibit a temporary phenotype of dry scaly skin that is resolved in an anterior-posterior direction
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• doxycycline-treated mice exhibit matrix cell apoptosis with DNA damage response unlike in control mice
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• in doxycycline-treated mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased apoptosis of cortical and central mesenchymal and epithelial cells
• normal apoptosis of stromal cells
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• increase in stromal tissue in newborns
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• cystic dilation of renal tubules in newborns
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• no mature glomeruli in E18.5 embryos and in newborns
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• reduced number of glomeruli in E16.5 embryos
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• reduced number of S-shaped bodies in E13.5 embryos with further reduction at E16.5
• immature comma- and S-shaped bodies in E16.5 embryos
• no mature glomeruli in E18.5 embryos and in newborns
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• thin and discontinuous cortical nephrogenic zone
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• smaller kidneys with reduced tubular structures in newborns
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• cystic dilation in newborns
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• at least one absent kidney in 36% of E16.5 embryos, both absent in 6.5%
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• early perinatal mortality: no offspring beyond weaning stage
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• increased apoptosis of cortical and central mesenchymal and epithelial cells
• normal apoptosis of stromal cells
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• smaller milk spot in newborns
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• in newborns
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• causing death within hours of birth
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• causing death within hours of birth
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• cystic dilation of renal tubules in newborns
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• causing death within hours of birth
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• gasping in newborns
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• females become ill at 2-3 weeks, exhibiting 100% mortality at <25 days
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• cuffing around blood vessels by inflammatory cells in pancreas, kidney and skeletal muscle is observed
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• moribund mice display splenomegaly
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• all leukocyte populations are expanded equally, except for consistent increase observed in CD8+ T cell number
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• decrease in Foxp3+ CD25lo population
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• increased frequencies of CD62Llo44hi CD4+ and CD8+ T cells are observed, indicating aberrant activation
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• moribund mice display massive lymphadenopathy at 2.5-3 weeks of age
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• hyper-Ifng secretion by CD4+ and CD8+ T cells is observed
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• hyper-Il-4 secretion by CD4+ T cells is observed
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• large areas are infiltrated by inflammatory cells in moribund mice
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• large areas are infiltrated by inflammatory cells in moribund mice
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• moribund mice display splenomegaly
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• all leukocyte populations are expanded equally, except for consistent increase observed in CD8+ T cell number
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|
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• decrease in Foxp3+ CD25lo population
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|
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• increased frequencies of CD62Llo44hi CD4+ and CD8+ T cells are observed, indicating aberrant activation
|
|
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• cuffing around blood vessels by inflammatory cells in pancreas, kidney and skeletal muscle is observed
|
|
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• large areas are infiltrated by inflammatory cells in moribund mice
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• large areas are infiltrated by inflammatory cells in moribund mice
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• moribund mice display splenomegaly
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• males become ill at 2-3 weeks, exhibiting 100% mortality at <25 days
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• cuffing around blood vessels by inflammatory cells in pancreas, kidney and skeletal muscle is observed
|
|
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• moribund mice display splenomegaly
|
|
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• all leukocyte populations are expanded equally, except for consistent increase observed in CD8+ T cell number
|
|
|
• increased frequencies of CD62Llo44hi CD4+ and CD8+ T cells are observed, indicating aberrant activation
|
|
|
• cuffing around blood vessels by inflammatory cells in pancreas, kidney and skeletal muscle is observed
|
|
|
• moribund mice display splenomegaly
|
|
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• all leukocyte populations are expanded equally, except for consistent increase observed in CD8+ T cell number
|
|
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• increased frequencies of CD62Llo44hi CD4+ and CD8+ T cells are observed, indicating aberrant activation
|
|
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• moribund mice display massive lymphadenopathy at 2.5-3 weeks of age
|
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• hyper-Ifng secretion by CD4+ and CD8+ T cells is observed
|
|
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• hyper-IL-4 secretion by CD4+ T cells is observed
|
|
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• large areas are infiltrated by inflammatory cells in moribund mice
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• large areas are infiltrated by inflammatory cells in moribund mice
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• large areas are infiltrated by inflammatory cells in moribund mice
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• large areas are infiltrated by inflammatory cells in moribund mice
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• moribund mice display splenomegaly
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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