Phenotypes associated with this allele

• Allele Symbol: Palb2^{Gt(CG0691)Wtsi}
• Allele Name: gene trap CG0691, Wellcome Trust Sanger Institute
• Allele ID: MGI:3801303
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Palb2^Gt(CG0691)Wtsi/Palb2^Gt(CG0691)Wtsi	involves: 129P2/OlaHsd * C57BL/6N	MGI:4462376

Genotype
MGI:4462376

hm1

• Allelic Composition: Palb2^{Gt(CG0691)Wtsi}/Palb2^{Gt(CG0691)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:161528 )

• live embryos are present at E7.5 but no live embryos are seen beyond E9.5

embryonic lethality between implantation and placentation, incomplete penetrance ( J:161528 )

• by E8.5 most embryos are reabsorbed or undergoing degeneration

embryo

decreased inner cell mass proliferation ( J:161528 )

• 85% of blastocysts show impaired outgrowth of the ICM

abnormal gastrulation ( J:161528 )

• at E7.5 the embryonic cavities are not properly formed

abnormal ectoderm development ( J:161528 )

• at E7.5 the embryonic ectoderm appears with an increased mass of cells

abnormal mesoderm development ( J:161528 )

• fails to differentiate properly by E8.5

decreased embryo size ( J:161528 )

• markedly smaller by E6.5

abnormal embryonic tissue morphology ( J:161528 )

• show improper organogenesis at E8.5

abnormal notochord morphology ( J:161528 )

• diffuse and discontinuous at E8.5

• fails to progress caudally at E8.5

absent somites ( J:161528 )

• at E8.5

abnormal tail bud morphology ( J:161528 )

• lack proper tail bud structures at E8.5

abnormal embryonic-extraembryonic boundary morphology ( J:161528 )

• poorly defined at E7.5

absent amnion ( J:161528 )

• undetectable at E7.5

limbs/digits/tail

abnormal tail bud morphology ( J:161528 )

• lack proper tail bud structures at E8.5

growth/size/body

decreased embryo size ( J:161528 )

• markedly smaller by E6.5

cellular

decreased inner cell mass proliferation ( J:161528 )

• 85% of blastocysts show impaired outgrowth of the ICM