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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Rr291-lacZ)#Mekk
transgene insertion, Marc Ekker
MGI:3802467
Summary 16 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Foxc1hith/Foxc1hith
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802474
cx2
 		m412Asp/m412Asp
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802475
cx3
 		Dync2h1m407Asp/Dync2h1m407Asp
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802478
cx4
 		Rdh10m366Asp/Rdh10m366Asp
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802479
cx5
 		m357Asp/m357Asp
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802481
cx6
 		Pcntm275Asp/Pcntm275Asp
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802482
cx7
 		Pcntm275Asp/Pcnt+
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802483
cx8
 		m251Asp/m251Asp
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802491
cx9
 		Pcntm239Asp/Pcntm239Asp
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802492
cx10
 		Pcntm239Asp/Pcnt+
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802494
cx11
 		m154Asp/m154Asp
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802495
cx12
 		m154Asp/m154Asp+
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802496
cx13
 		Dync2h1m152Asp/Dync2h1m152Asp
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802499
cx14
 		Scribm90Asp/Scribm90Asp
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802500
cx15
 		Rfx4m269Asp/Rfx4m269Asp
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802502
cx16
 		Lrp2m267Asp/Lrp2m267Asp
Tg(Rr291-lacZ)#Mekk/0 		involves: C57BL/6J * FVB/N MGI:3802503


Genotype
MGI:3802474
cx1
Allelic
Composition		 Foxc1hith/Foxc1hith
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1hith mutation (0 available); any Foxc1 mutation (29 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex morphology ( J:136795 )
• at E14.5, mice exhibit midline cortical hypertrophy




Genotype
MGI:3802475
cx2
Allelic
Composition		 m412Asp/m412Asp
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex morphology ( J:136795 )
• at E14.5, mice exhibit a failure of the thalamocortical axons to invade the cortex
• the intermediate zone of the cortex is thinner than in wild-type mice




Genotype
MGI:3802478
cx3
Allelic
Composition		 Dync2h1m407Asp/Dync2h1m407Asp
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dync2h1m407Asp mutation (0 available); any Dync2h1 mutation (215 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal forebrain development ( J:136795 )
• at E14.5, mice exhibit dorsoventral forebrain patterning defects




Genotype
MGI:3802479
cx4
Allelic
Composition		 Rdh10m366Asp/Rdh10m366Asp
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rdh10m366Asp mutation (0 available); any Rdh10 mutation (20 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
thin cerebral cortex ( J:136795 )
• at E14.5, mice exhibit a thinner but expanded cortex compared to wild-type mice




Genotype
MGI:3802481
cx5
Allelic
Composition		 m357Asp/m357Asp
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system

craniofacial
abnormal facial morphology ( J:136795 )
• mice exhibit midline facial defects

growth/size/body
abnormal facial morphology ( J:136795 )
• mice exhibit midline facial defects




Genotype
MGI:3802482
cx6
Allelic
Composition		 Pcntm275Asp/Pcntm275Asp
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcntm275Asp mutation (0 available); any Pcnt mutation (159 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal cerebral cortex morphology ( J:136795 )
• at E14.5, mice exhibit abnormal interneuron migration in the cerebral cortex
• the crispness of the boundary between the subventricular zone and the stream of migrating cells is lost

limbs/digits/tail
polydactyly ( J:136795 )
• anterior




Genotype
MGI:3802483
cx7
Allelic
Composition		 Pcntm275Asp/Pcnt+
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcntm275Asp mutation (0 available); any Pcnt mutation (159 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:136795 )
• mortality among young adults is increased compared to in wild-type mice

nervous system

behavior/neurological




Genotype
MGI:3802491
cx8
Allelic
Composition		 m251Asp/m251Asp
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal cerebral cortex morphology ( J:136795 )
• at E14.5, mice exhibit abnormal interneuron migration in the cerebral cortex

limbs/digits/tail
polydactyly ( J:136795 )
• anterior




Genotype
MGI:3802492
cx9
Allelic
Composition		 Pcntm239Asp/Pcntm239Asp
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcntm239Asp mutation (0 available); any Pcnt mutation (159 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex morphology ( J:136795 )
• at E14.5, mice exhibit abnormal interneuron migration in the cerebral cortex
• the crispness of the boundary between the subventricular zone and the stream of migrating cells is lost

limbs/digits/tail
polydactyly ( J:136795 )
• anterior




Genotype
MGI:3802494
cx10
Allelic
Composition		 Pcntm239Asp/Pcnt+
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcntm239Asp mutation (0 available); any Pcnt mutation (159 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:136795 )
• mortality among young adults is increased compared to in wild-type mice

behavior/neurological

nervous system




Genotype
MGI:3802495
cx11
Allelic
Composition		 m154Asp/m154Asp
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal cerebral cortex morphology ( J:136795 )
• at E14.5, mice exhibit abnormal interneuron migration in the cerebral cortex




Genotype
MGI:3802496
cx12
Allelic
Composition		 m154Asp/m154Asp+
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:136795 )
• mortality among young adults is increased compared to in wild-type mice

behavior/neurological

nervous system




Genotype
MGI:3802499
cx13
Allelic
Composition		 Dync2h1m152Asp/Dync2h1m152Asp
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dync2h1m152Asp mutation (0 available); any Dync2h1 mutation (215 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex morphology ( J:136795 )
• at E14.5, mice exhibit a small posteriorly misshapen cortex




Genotype
MGI:3802500
cx14
Allelic
Composition		 Scribm90Asp/Scribm90Asp
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scribm90Asp mutation (0 available); any Scrib mutation (54 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal embryonic neuroepithelium morphology ( J:136795 )
• at E12.5, the neuroepithelium is disorganized and hyperplastic in the cortex and other parts of the nervous system
open neural tube ( J:136795 )
• at the spinal cord and hindbrain at E12.5
abnormal cerebral cortex morphology ( J:136795 )
• at E14.5, mice exhibit altered epithelial polarity

embryo
abnormal embryonic neuroepithelium morphology ( J:136795 )
• at E12.5, the neuroepithelium is disorganized and hyperplastic in the cortex and other parts of the nervous system
open neural tube ( J:136795 )
• at the spinal cord and hindbrain at E12.5




Genotype
MGI:3802502
cx15
Allelic
Composition		 Rfx4m269Asp/Rfx4m269Asp
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rfx4m269Asp mutation (0 available); any Rfx4 mutation (48 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex morphology ( J:136795 )
• mice exhibit defect in dorsal midline of the cortex morphology
• dorsal midline structures are lost in the mutant




Genotype
MGI:3802503
cx16
Allelic
Composition		 Lrp2m267Asp/Lrp2m267Asp
Tg(Rr291-lacZ)#Mekk/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp2m267Asp mutation (0 available); any Lrp2 mutation (261 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
choroid plexus hyperplasia ( J:136795 )
• in the third ventricle at E14.5
abnormal diencephalon morphology ( J:136795 )
• at E17.5, the dorsal diencephalons is abnormal
abnormal cerebral cortex morphology ( J:136795 )
• at E14.5, the cortex is enlarged in the rostrocaudal axis and abnormally shaped




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory