All Phenotypes Zfpm2<tm2Sho> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zfpm2^tm2Sho
targeted mutation 2, Stuart Orkin
MGI:3802480

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfpm2^tm2Sho/Zfpm2^tm2Sho	involves: 129 * C57BL/6J	MGI:3709975
hm2	Zfpm2^tm2Sho/Zfpm2^tm2Sho	involves: 129S1/Sv	MGI:3851412
cn3	Zfpm2^tm1Sho/Zfpm2^tm2Sho Tg(Wap-cre)11738Mam/0	involves: 129 * C57BL/6J * C57BL/6NCr	MGI:3709976
cn4	Wt1^{tm1(EGFP/cre)Wtp}/Wt1⁺ Zfpm2^tm1Sho/Zfpm2^tm2Sho	involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd	MGI:3851402
cn5	Zfpm2^tm1Sho/Zfpm2^tm2Sho Tg(Tnnt2-rtTA,tetO-cre)1Wtp/0	involves: 129S1/Sv * 129S7/SvEvBrd	MGI:3851407
cn6	Zfpm2^tm1Sho/Zfpm2^tm2Sho Tg(Myh6-cre)2182Mds/0	involves: 129S1/Sv * 129S7/SvEvBrd	MGI:3851401
cn7	Zfpm2^tm1Sho/Zfpm2^tm2Sho Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺	involves: 129S1/Sv * 129S7/SvEvBrd	MGI:3851399
cn8	Zfpm2^tm1Sho/Zfpm2^tm2Sho H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3851405
cn9	Zfpm2^tm1Sho/Zfpm2^tm2Sho Tg(Tek-cre)1Ywa/0	involves: 129S1/Sv * C57BL/6 * SJL	MGI:3851403

Allelic Composition	Zfpm2^tm2Sho/Zfpm2^tm2Sho
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfpm2^tm2Sho mutation (1 available); any Zfpm2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:120985 )

• mice are viable, fertile and show no obvious abnormalities

Allelic Composition	Zfpm2^tm2Sho/Zfpm2^tm2Sho
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfpm2^tm2Sho mutation (1 available); any Zfpm2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal myocardial fiber physiology ( J:150452 )

• neonatal cardiomyocytes treated in culture with adeno-cre display significantly decreased quality and quantity of tubule formation

• inactivation of Zfpm2 in cardiomyocytes decreases proliferation of human umbilical vein endothelial cells in co-culture

Allelic Composition	Zfpm2^tm1Sho/Zfpm2^tm2Sho Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129 * C57BL/6J * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wap-cre)11738Mam mutation (3 available)
Zfpm2^tm1Sho mutation (2 available); any Zfpm2 mutation (47 available)
Zfpm2^tm2Sho mutation (1 available); any Zfpm2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:120985 )

N	• mice are fertile

endocrine/exocrine glands

abnormal mammary gland morphology ( J:120985 )

• at day 4 of involution, alveoli are completely collapsed into clusters of epithelial cells and the area containing adipocytes is greatly expanded

• however, after 6 days of involution there is no difference when compared to controls

abnormal involution of the mammary gland ( J:120985 )

• involution occurs faster at days 3 and 4 of involution than in controls

integument

abnormal mammary gland morphology ( J:120985 )

• at day 4 of involution, alveoli are completely collapsed into clusters of epithelial cells and the area containing adipocytes is greatly expanded

• however, after 6 days of involution there is no difference when compared to controls

abnormal involution of the mammary gland ( J:120985 )

• involution occurs faster at days 3 and 4 of involution than in controls

Allelic Composition	Wt1^{tm1(EGFP/cre)Wtp}/Wt1⁺ Zfpm2^tm1Sho/Zfpm2^tm2Sho
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wt1^{tm1(EGFP/cre)Wtp} mutation (1 available); any Wt1 mutation (34 available)
Zfpm2^tm1Sho mutation (2 available); any Zfpm2 mutation (47 available)
Zfpm2^tm2Sho mutation (1 available); any Zfpm2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:150452 )

• pups die in perinatal period

cardiovascular system

cardiovascular system phenotype ( J:150452 )

N	• coronary vascular development is not impaired

thin myocardium compact layer ( J:150452 )

• compact myocardium is thin

abnormal atrioventricular cushion morphology ( J:150452 )

• severe atrio-ventricular endocardial cushion defect is observed by E14.5

muscle

thin myocardium compact layer ( J:150452 )

• compact myocardium is thin

Allelic Composition	Zfpm2^tm1Sho/Zfpm2^tm2Sho Tg(Tnnt2-rtTA,tetO-cre)1Wtp/0
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tnnt2-rtTA,tetO-cre)1Wtp mutation (0 available)
Zfpm2^tm1Sho mutation (2 available); any Zfpm2 mutation (47 available)
Zfpm2^tm2Sho mutation (1 available); any Zfpm2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Increased fibrotic tissues in doxycycline-treated Zfpm2^tm1Sho/Zfpm2^tm2Sho Tg(Tnnt2-rtTA,tetO-cre)1Wtp/0 hearts

cardiovascular system

abnormal cardiovascular development ( J:150452 )

• decreased coronary vasculature is observed in doxycycline-treated mice relative to controls

decreased cardiac muscle contractility ( J:150452 )

• significantly diminished fractional shortening is observed in mice receiving doxycycline-treated water from 4 to 8 weeks of age

• fractional shortening progressively decreases in animals treated with doxycycline

muscle

decreased cardiac muscle contractility ( J:150452 )

• significantly diminished fractional shortening is observed in mice receiving doxycycline-treated water from 4 to 8 weeks of age

• fractional shortening progressively decreases in animals treated with doxycycline

increased cardiomyocyte apoptosis ( J:150452 )

• level of apoptosis is elevated compared to controls

cellular

increased cardiomyocyte apoptosis ( J:150452 )

• level of apoptosis is elevated compared to controls

Allelic Composition	Zfpm2^tm1Sho/Zfpm2^tm2Sho Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre)2182Mds mutation (3 available)
Zfpm2^tm1Sho mutation (2 available); any Zfpm2 mutation (47 available)
Zfpm2^tm2Sho mutation (1 available); any Zfpm2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Dilated cardiomyopathy in Zfpm2^tm1Sho/Zfpm2^tm2Sho Tg(Myh6-cre)2182Mds/0 mice

mortality/aging

premature death ( J:150452 )

• mice survive normally to weaning but die at 8-12 weeks

postnatal lethality, complete penetrance ( J:150452 )

cardiovascular system

cardiovascular system phenotype ( J:150452 )

N	• at E14.5 no structural heart defects or coronary vascular plexus abnormalities are observed • myocardium thickens normally and contains normal number of intramyocardial vessels

abnormal cardiovascular development ( J:150452 )

• decreased coronary vasculature is observed in adults

• density of PECAM positive vessels particularly capillaries are reduced in density; coronary arteriole density is also decreased

cardiac fibrosis ( J:150452 )

• significantly increased and replaces apoptotic tissues

dilated heart ( J:150452 )

• adult hearts are dilated

dilated heart ventricle ( J:150452 )

• ventricular dilation is observed

abnormal coronary circulation ( J:150452 )

• decreased myocardial perfusion is observed in adults, resulting in tissue hypoxia

decreased cardiac muscle contractility ( J:150452 )

• fractional shortening is severely depressed in adults

decreased heart ventricle muscle contractility ( J:150452 )

• contraction is depressed in adults

muscle

decreased cardiac muscle contractility ( J:150452 )

• fractional shortening is severely depressed in adults

decreased heart ventricle muscle contractility ( J:150452 )

• contraction is depressed in adults

increased cardiomyocyte apoptosis ( J:150452 )

• significantly increased in adult heart compared to controls

cellular

increased cardiomyocyte apoptosis ( J:150452 )

• significantly increased in adult heart compared to controls

Allelic Composition	Zfpm2^tm1Sho/Zfpm2^tm2Sho Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5^tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
Zfpm2^tm1Sho mutation (2 available); any Zfpm2 mutation (47 available)
Zfpm2^tm2Sho mutation (1 available); any Zfpm2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Abnormal heart development and coronary vasculogenesis in Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Zfpm2^tm1Sho/Zfpm2^tm2Sho mice

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:150452 )

• embryos die by E13.5-E14.5

cardiovascular system

thin myocardium compact layer ( J:150452 )

• compact myocardium is thin

abnormal atrioventricular cushion morphology ( J:150452 )

• atrio-ventricular cushion defect is observed

abnormal coronary vessel morphology ( J:150452 )

• coronary vascular plexus is significantly decreased compared to controls; myocardium contains few coronary vessels

overriding aortic valve ( J:150452 )

atrial septal defect ( J:150452 )

• large atrial septal defect is observed in embryos

ventricular septal defect ( J:150452 )

• large ventricular septal defect is observed

pericardial effusion ( J:150452 )

• embryos display pericardial effusion prior to death

hemorrhage ( J:150452 )

• embryos display hemorrhage prior to death

homeostasis/metabolism

pericardial effusion ( J:150452 )

• embryos display pericardial effusion prior to death

skin edema ( J:150452 )

• embryos develop subcutaneous edema prior to death

integument

skin edema ( J:150452 )

• embryos develop subcutaneous edema prior to death

muscle

thin myocardium compact layer ( J:150452 )

• compact myocardium is thin

Allelic Composition	Zfpm2^tm1Sho/Zfpm2^tm2Sho H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Zfpm2^tm1Sho mutation (2 available); any Zfpm2 mutation (47 available)
Zfpm2^tm2Sho mutation (1 available); any Zfpm2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:150452 )

N	• mice survive normally

cardiovascular system

cardiovascular system phenotype ( J:150452 )

N	• no detectable defects in heart morphogenesis or coronary development are detected

Allelic Composition	Zfpm2^tm1Sho/Zfpm2^tm2Sho Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tek-cre)1Ywa mutation (6 available)
Zfpm2^tm1Sho mutation (2 available); any Zfpm2 mutation (47 available)
Zfpm2^tm2Sho mutation (1 available); any Zfpm2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:150452 )

N	• survival rate to weaning is normal

cardiovascular system

cardiovascular system phenotype ( J:150452 )

N	• coronary plexus, endocardial cushions and compact myocardial layer develop normally • adults have normal tricuspid and mitral valves

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