Analysis Tools
normal phenotype
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• mice are viable, fertile and show no obvious abnormalities
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Allele Symbol Allele Name Allele ID |
Zfpm2tm2Sho targeted mutation 2, Stuart Orkin MGI:3802480 |
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| Summary |
9 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are viable, fertile and show no obvious abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• neonatal cardiomyocytes treated in culture with adeno-cre display significantly decreased quality and quantity of tubule formation
• inactivation of Zfpm2 in cardiomyocytes decreases proliferation of human umbilical vein endothelial cells in co-culture
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice are fertile
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• at day 4 of involution, alveoli are completely collapsed into clusters of epithelial cells and the area containing adipocytes is greatly expanded
• however, after 6 days of involution there is no difference when compared to controls
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• involution occurs faster at days 3 and 4 of involution than in controls
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• at day 4 of involution, alveoli are completely collapsed into clusters of epithelial cells and the area containing adipocytes is greatly expanded
• however, after 6 days of involution there is no difference when compared to controls
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• involution occurs faster at days 3 and 4 of involution than in controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pups die in perinatal period
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| N |
• coronary vascular development is not impaired
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• compact myocardium is thin
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• severe atrio-ventricular endocardial cushion defect is observed by E14.5
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• compact myocardium is thin
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Increased fibrotic tissues in doxycycline-treated Zfpm2tm1Sho/Zfpm2tm2Sho Tg(Tnnt2-rtTA,tetO-cre)1Wtp/0 hearts
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• decreased coronary vasculature is observed in doxycycline-treated mice relative to controls
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• significantly diminished fractional shortening is observed in mice receiving doxycycline-treated water from 4 to 8 weeks of age
• fractional shortening progressively decreases in animals treated with doxycycline
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• significantly diminished fractional shortening is observed in mice receiving doxycycline-treated water from 4 to 8 weeks of age
• fractional shortening progressively decreases in animals treated with doxycycline
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• level of apoptosis is elevated compared to controls
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• level of apoptosis is elevated compared to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Dilated cardiomyopathy in Zfpm2tm1Sho/Zfpm2tm2Sho Tg(Myh6-cre)2182Mds/0 mice
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• mice survive normally to weaning but die at 8-12 weeks
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| N |
• at E14.5 no structural heart defects or coronary vascular plexus abnormalities are observed
• myocardium thickens normally and contains normal number of intramyocardial vessels
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• decreased coronary vasculature is observed in adults
• density of PECAM positive vessels particularly capillaries are reduced in density; coronary arteriole density is also decreased
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• significantly increased and replaces apoptotic tissues
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• adult hearts are dilated
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• ventricular dilation is observed
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• decreased myocardial perfusion is observed in adults, resulting in tissue hypoxia
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• fractional shortening is severely depressed in adults
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• contraction is depressed in adults
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• fractional shortening is severely depressed in adults
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• contraction is depressed in adults
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• significantly increased in adult heart compared to controls
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• significantly increased in adult heart compared to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Abnormal heart development and coronary vasculogenesis in Nkx2-5tm1(cre)Rjs/Nkx2-5+ Zfpm2tm1Sho/Zfpm2tm2Sho mice
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• embryos die by E13.5-E14.5
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• compact myocardium is thin
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• atrio-ventricular cushion defect is observed
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• coronary vascular plexus is significantly decreased compared to controls; myocardium contains few coronary vessels
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• large atrial septal defect is observed in embryos
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• large ventricular septal defect is observed
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• embryos display pericardial effusion prior to death
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• embryos display hemorrhage prior to death
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• embryos display pericardial effusion prior to death
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• embryos develop subcutaneous edema prior to death
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• embryos develop subcutaneous edema prior to death
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• compact myocardium is thin
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice survive normally
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| N |
• no detectable defects in heart morphogenesis or coronary development are detected
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• survival rate to weaning is normal
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| N |
• coronary plexus, endocardial cushions and compact myocardial layer develop normally
• adults have normal tricuspid and mitral valves
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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