About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ppargc1btm1Dpk
targeted mutation 1, Daniel P Kelly
MGI:3802518
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ppargc1atm2Brsp/Ppargc1atm2Brsp
Ppargc1btm1Dpk/Ppargc1btm1Dpk
Tg(Tyr-cre)1Lru/0
involves: 129 * 129X1/SvJ * C57BL/6 MGI:6272349
cn2
Ppargc1atm1Dpk/Ppargc1atm1Dpk
Ppargc1btm1Dpk/Ppargc1btm1Dpk
Tg(Myh6-cre)2182Mds/0
involves: 129X1/SvJ * FVB/N MGI:3802663


Genotype
MGI:6272349
cn1
Allelic
Composition
Ppargc1atm2Brsp/Ppargc1atm2Brsp
Ppargc1btm1Dpk/Ppargc1btm1Dpk
Tg(Tyr-cre)1Lru/0
Genetic
Background
involves: 129 * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargc1atm2Brsp mutation (0 available); any Ppargc1a mutation (48 available)
Ppargc1btm1Dpk mutation (1 available); any Ppargc1b mutation (57 available)
Tg(Tyr-cre)1Lru mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
N
• on a C57BL/6 background, mice show no change in baseline coat color relative to control mice




Genotype
MGI:3802663
cn2
Allelic
Composition
Ppargc1atm1Dpk/Ppargc1atm1Dpk
Ppargc1btm1Dpk/Ppargc1btm1Dpk
Tg(Myh6-cre)2182Mds/0
Genetic
Background
involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargc1atm1Dpk mutation (1 available); any Ppargc1a mutation (48 available)
Ppargc1btm1Dpk mutation (1 available); any Ppargc1b mutation (57 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 67% of mice die within 24 hours of birth

cardiovascular system
• after birth, myocytes exhibit a reduction in mitochondrial number and size compared to in wild-type mice
• similar to that found in Ppargc1atm1Dpk Ppargc1btm1.1Dpk homozygotes

muscle
• after birth, myocytes exhibit a reduction in mitochondrial number and size compared to in wild-type mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory