All Phenotypes Eomes<tm1Srnr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Eomes^tm1Srnr
targeted mutation 1, Steven Reiner
MGI:3802572

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Eomes^tm1Srnr/Eomes^tm1Srnr Tg(Cd4-cre)1Cwi/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:3804632
cn2	Eomes^tm1Srnr/Eomes^tm1Srnr Tbx21^tm1Srnr/Tbx21^tm1Srnr Tg(Cd4-cre)1Cwi/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:3804634

Allelic Composition	Eomes^tm1Srnr/Eomes^tm1Srnr Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomes^tm1Srnr mutation (1 available); any Eomes mutation (44 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:137655 )

N	• unlike mice with T-cell specific conditional deletion of Eomes that also lack expression of Tbx21, clearance of lymphocyte choriomeningitis virus is similar to wild-type controls

decreased memory T cell number ( J:137655 )

• deficiency in memory-phenotype CD8+ T cells

hematopoietic system

decreased memory T cell number ( J:137655 )

• deficiency in memory-phenotype CD8+ T cells

Allelic Composition	Eomes^tm1Srnr/Eomes^tm1Srnr Tbx21^tm1Srnr/Tbx21^tm1Srnr Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomes^tm1Srnr mutation (1 available); any Eomes mutation (44 available)
Tbx21^tm1Srnr mutation (0 available); any Tbx21 mutation (39 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased neutrophil cell number ( J:137655 )

abnormal T cell morphology ( J:137655 )

abnormal CD8-positive, alpha-beta T cell differentiation ( J:137655 )

• impaired cytotoxic CD8+ T cell differentiation following viral infection

• following viral infection, differentiation is skewed exclusively toward the Type 17 fate

decreased CD8-positive, alpha-beta T cell number ( J:137655 )

• defect in accumulation of CD8+ T cells following viral infection

decreased memory T cell number ( J:137655 )

• deficiency in memory-phenotype CD8+ T cells

abnormal immune system physiology ( J:137655 )

abnormal leukocyte physiology ( J:137655 )

• CD8+ T cells have a severe defect in cytotoxic gene expression in response to viral peptide stimulation even when cellularity is normalized

abnormal interleukin level ( J:137655 )

• increase in IL17 expression in CD8+ T cells in response to stimulation with viral derived peptides

increased susceptibility to Riboviria infection ( J:137655 )

• persistent high titers of lymphocyte choriomeningitis virus

• progressive weight loss, not seen in controls, begins about 1 week after infection and is accompanied by extensive organ pathology and excessive neutrophil response

• depletion of CD8+ T cells prevents viral induced wasting, neutrophilia, and organ pathology

homeostasis/metabolism

abnormal interleukin level ( J:137655 )

• increase in IL17 expression in CD8+ T cells in response to stimulation with viral derived peptides

hematopoietic system

increased neutrophil cell number ( J:137655 )

abnormal T cell morphology ( J:137655 )

abnormal CD8-positive, alpha-beta T cell differentiation ( J:137655 )

• impaired cytotoxic CD8+ T cell differentiation following viral infection

• following viral infection, differentiation is skewed exclusively toward the Type 17 fate

decreased CD8-positive, alpha-beta T cell number ( J:137655 )

• defect in accumulation of CD8+ T cells following viral infection

decreased memory T cell number ( J:137655 )

• deficiency in memory-phenotype CD8+ T cells

abnormal leukocyte physiology ( J:137655 )

• CD8+ T cells have a severe defect in cytotoxic gene expression in response to viral peptide stimulation even when cellularity is normalized

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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