Phenotypes associated with this allele

• Allele Symbol: Twsg1^tm1Ecan
• Allele Name: targeted mutation 1, Ernesto Canalis
• Allele ID: MGI:3802605
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Twsg1^tm1Ecan/Twsg1^tm1Ecan	involves: 129 * C57BL/6	MGI:3803747

Genotype
MGI:3803747

hm1

• Allelic Composition: Twsg1^tm1Ecan/Twsg1^tm1Ecan
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:137597 )

• homozygotes comprise only 10% of pups recovered from crossing heterozygotes rather than the expected 25%

• reduced viability

growth/size/body

decreased body size ( J:137597 )

• surviving homozygotes are about 30% smaller than controls

limbs/digits/tail

short femur ( J:137597 )

• 25% reduction in length at 4 weeks of age

• length normal at 7 weeks of age or later

abnormal tail morphology ( J:137597 )

short tail ( J:137597 )

• radiological evidence

kinked tail ( J:137597 )

• radiological evidence

homeostasis/metabolism

decreased circulating osteocalcin level ( J:137597 )

• osteocalcin levels in serum reduced by 70% at 4 weeks of age

• osteocalcin levels in serum normal at 7 weeks of age or later

skeleton

abnormal skeleton morphology ( J:137597 )

short femur ( J:137597 )

• 25% reduction in length at 4 weeks of age

• length normal at 7 weeks of age or later

decreased bone mineral content ( J:137597 )

• 40% reduction in bone mineral content at 4 weeks of age

• bone mineral content is normal at 7 weeks of age and later

decreased bone volume ( J:137597 )

• transient reduction in bone volume

decreased trabecular bone volume ( J:137597 )

• 46% reduction in trabecular bone volume at 4 weeks of age

decreased bone trabecula number ( J:137597 )

• non-significant 25% reduction in trabecular number at 4 weeks of age

abnormal skeleton development ( J:137597 )

• osteoblast number /perimeter and osteblast function are normal

• absolute number of osteoblasts is reduced