All Phenotypes Lasp1<tm1Chew> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lasp1^tm1Chew
targeted mutation 1, Catherine S Chew
MGI:3802612

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lasp1^tm1Chew/Lasp1^tm1Chew	B6.129X1-Lasp1^tm1Chew	MGI:3803669
hm2	Lasp1^tm1Chew/Lasp1^tm1Chew	involves: 129X1/SvJ * C57BL/6J	MGI:3803668

Allelic Composition	Lasp1^tm1Chew/Lasp1^tm1Chew
Genetic Background	B6.129X1-Lasp1^tm1Chew

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lasp1^tm1Chew mutation (1 available); any Lasp1 mutation (170 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:137526 )

N	• despite increased gastric secretion upon stimulation with histamine, parietal cell morphology and numbers in the glandular units are normal

excessive digestive secretion ( J:137526 )

• gastric acid secretory response to histamine is increased compared to in wild-type mice

• however, basal secretions are normal

growth/size/body

decreased body weight ( J:137526 )

• despite normal growth rates, small reduction in body weight persists for 6 months

reproductive system

reproductive system phenotype ( J:137526 )

N	• unlike mice maintained on a mixed background, mice exhibit normal testes and seminal vesicle size

cardiovascular system

cardiovascular system phenotype ( J:137526 )

N	• unlike mice maintained on a mixed background, mice exhibit normal heart size

skeleton

skeleton phenotype ( J:137526 )

N	• despite expression in osteoclasts, the number of osteoclasts, bone size and bone-forming surfaces are normal

Allelic Composition	Lasp1^tm1Chew/Lasp1^tm1Chew
Genetic Background	involves: 129X1/SvJ * C57BL/6J