All Phenotypes Tg(MMTV-cre)#Mam MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Chek1^tm2.1Sje/Chek1⁺ Trp53^tm1Brn/Trp53⁺ Tg(MMTV-cre)#Mam/0	involves: 129P2/OlaHsd * FVB	MGI:4818619
cn2	Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)#Mam/0	involves: 129P2/OlaHsd * FVB	MGI:4818620
cn3	Chek1^tm2.1Sje/Chek1⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)#Mam/0	involves: 129P2/OlaHsd * FVB	MGI:4818610
cn4	Chek1^tm2.1Sje/Chek1^tm2.1Sje Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)#Mam/0	involves: 129P2/OlaHsd * FVB	MGI:4818615
cn5	Chek1^tm2.1Sje/Chek1^tm2.1Sje Trp53^tm1Brn/Trp53⁺ Tg(MMTV-cre)#Mam/0	involves: 129P2/OlaHsd * FVB	MGI:4818618
cn6	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Bcl2l1^tm1.1Mam/Bcl2l1^tm1.1Mam Tg(MMTV-cre)#Mam/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB	MGI:3819938
cn7	Pik3ca^tm1.1Waph/Pik3ca⁺ Tg(MMTV-cre)#Mam/0	involves: 129S1/Sv * C57BL/6 * FVB	MGI:5755852
cn8	Stat1^tm1Mam/Stat1^tm1Mam Tg(MMTV-cre)#Mam/0	involves: 129S/SvEv * FVB	MGI:4942394
cn9	Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi} Tg(MMTV-cre)#Mam/0 Tg(MMTV-PyVT)634Mul/0	involves: C57BL/6N * FVB * FVB/N	MGI:5825266
cn10	Chek1^tm2.1Sje/Chek1⁺ Tg(MMTV-cre)#Mam/0	involves: FVB	MGI:4818608
cn11	Chek1^tm2.1Sje/Chek1^tm2.1Sje Tg(MMTV-cre)#Mam/0	involves: FVB	MGI:4818609

Allelic Composition	Chek1^tm2.1Sje/Chek1⁺ Trp53^tm1Brn/Trp53⁺ Tg(MMTV-cre)#Mam/0
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1^tm2.1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(MMTV-cre)#Mam mutation (0 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

abnormal tumor vascularization ( J:162126 )

• extensive with patches of reduced angiogenesis

increased mammary gland tumor incidence ( J:162126 )

• 20 of 33 mice develop mammary gland tumors with a median latency of 10.5 months unlike wild-type mice

increased mammary adenocarcinoma incidence ( J:162126 )

abnormal tumor morphology ( J:162126 )

• tumors are more complex than in Trp53^tm1Brn Tg(MMTV-cre)Mam homozygotes

• tumors exhibit aneuploidy and chromosomal aberrations

cellular

abnormal chromosome morphology ( J:162126 )

• in tumors

aneuploidy ( J:162126 )

• in tumors

cardiovascular system

abnormal tumor vascularization ( J:162126 )

• extensive with patches of reduced angiogenesis

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:162126 )

• at 12 months, mammary glands exhibit increased branching morphogenesis and hyperplastic foci compared to in wild-type mice

abnormal mammary gland alveolus morphology ( J:162126 )

• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

increased mammary gland tumor incidence ( J:162126 )

• 20 of 33 mice develop mammary gland tumors with a median latency of 10.5 months unlike wild-type mice

increased mammary adenocarcinoma incidence ( J:162126 )

mammary gland hyperplasia ( J:162126 )

• starting at 12 months, mammary glands exhibit hyperplastic and non-invasive focal lesions unlike wild-type mice

integument

abnormal branching of the mammary ductal tree ( J:162126 )

• at 12 months, mammary glands exhibit increased branching morphogenesis and hyperplastic foci compared to in wild-type mice

abnormal mammary gland alveolus morphology ( J:162126 )

• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

increased mammary gland tumor incidence ( J:162126 )

• 20 of 33 mice develop mammary gland tumors with a median latency of 10.5 months unlike wild-type mice

increased mammary adenocarcinoma incidence ( J:162126 )

mammary gland hyperplasia ( J:162126 )

• starting at 12 months, mammary glands exhibit hyperplastic and non-invasive focal lesions unlike wild-type mice

Allelic Composition	Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)#Mam/0
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-cre)#Mam mutation (0 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

abnormal tumor morphology ( J:162126 )

• tumors are less complex than in mice with one or two Chek1^tm2.1Sje alleles

increased tumor incidence ( J:162126 )

• mice exhibit increased tumor incidence compared to in mice with one or two Chek1^tm2.1Sje alleles

increased mammary gland tumor incidence ( J:162126 )

• in 5 of 10 mouse at 8 months of age

• in 1 of 10 mouse at 13 months of age

increased lymphoma incidence ( J:162126 )

• in 4 of 10 mouse at 7 to 8 months of age

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:162126 )

• in 5 of 10 mouse at 8 months of age

• in 1 of 10 mouse at 13 months of age

integument

increased mammary gland tumor incidence ( J:162126 )

• in 5 of 10 mouse at 8 months of age

• in 1 of 10 mouse at 13 months of age

Allelic Composition	Chek1^tm2.1Sje/Chek1⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)#Mam/0
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:162126 )

• 7 of 11 mice develop mammary gland tumors with a latency of 9 months unlike wild-type mice

decreased tumor incidence ( J:162126 )

• mice develop fewer tumors than in Trp53^tm1Brn Tg(MMTV-cre)Mam homozygotes

endocrine/exocrine glands

abnormal mammary gland alveolus morphology ( J:162126 )

• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

increased mammary gland tumor incidence ( J:162126 )

• 7 of 11 mice develop mammary gland tumors with a latency of 9 months unlike wild-type mice

mammary gland hyperplasia ( J:162126 )

• mammary glands exhibit multifocal hyperplasia unlike in wild-type mice that are more uniform than in Chek1^tm2.1Sje Trp53^tm1Brn Tg(MMTV-cre)Mam heterozygotes

integument

abnormal mammary gland alveolus morphology ( J:162126 )

• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

increased mammary gland tumor incidence ( J:162126 )

• 7 of 11 mice develop mammary gland tumors with a latency of 9 months unlike wild-type mice

mammary gland hyperplasia ( J:162126 )

• mammary glands exhibit multifocal hyperplasia unlike in wild-type mice that are more uniform than in Chek1^tm2.1Sje Trp53^tm1Brn Tg(MMTV-cre)Mam heterozygotes

Allelic Composition	Chek1^tm2.1Sje/Chek1^tm2.1Sje Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)#Mam/0
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:162126 )

N	• mammary glands do not exhibit hyperplastic foci

neoplasm

abnormal tumor morphology ( J:162126 )

• tumors are more complex than in Trp53^tm1Brn Tg(MMTV-cre)Mam homozygotes

decreased tumor incidence ( J:162126 )

• mice develop fewer tumors than in Trp53^tm1Brn Tg(MMTV-cre)Mam homozygotes

endocrine/exocrine glands

abnormal mammary gland alveolus morphology ( J:162126 )

• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

integument

abnormal mammary gland alveolus morphology ( J:162126 )

• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

Allelic Composition	Chek1^tm2.1Sje/Chek1^tm2.1Sje Trp53^tm1Brn/Trp53⁺ Tg(MMTV-cre)#Mam/0
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:162126 )

• 3 of 21 mice develop mammary gland tumors with a latency of 21 months unlike wild-type mice

endocrine/exocrine glands

abnormal mammary gland alveolus morphology ( J:162126 )

• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

increased mammary gland tumor incidence ( J:162126 )

• 3 of 21 mice develop mammary gland tumors with a latency of 21 months unlike wild-type mice

integument

abnormal mammary gland alveolus morphology ( J:162126 )

• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

increased mammary gland tumor incidence ( J:162126 )

• 3 of 21 mice develop mammary gland tumors with a latency of 21 months unlike wild-type mice

Allelic Composition	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Bcl2l1^tm1.1Mam/Bcl2l1^tm1.1Mam Tg(MMTV-cre)#Mam/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1^tm1Thsn mutation (2 available); any Bak1 mutation (25 available)
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Bax^tm2Sjk mutation (1 available); any Bax mutation (24 available)
Bcl2l1^tm1.1Mam mutation (0 available); any Bcl2l1 mutation (104 available)
Tg(MMTV-cre)#Mam mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:141545 )

N	• unlike in Bcl2l1^tm1.1Mam/Bcl2l1^tm1.1Mam Tg(MMTV-cre)Mam mice or Bnip3l^tm1Ney homozygotes, spleen size, red blood cell numbers and reticulocytes clear of mitochondria are normal

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:187299 )

• nulliparous mice show a median tumor-free survival of 484 days, while biparous mice show a median tumor-free survival of 393 days

endocrine/exocrine glands

increased mammary gland epithelial cell proliferation ( J:187299 )

• increase in proliferation within the multilayered epithelia of the mammary ducts

• colony forming ability of the luminal progenitors is enhanced

abnormal mammary gland epithelium morphology ( J:187299 )

• loss of polarity in the mammary gland epithelium

• the luminal cell population (Lin-CD29loCD24+) and luminal progenitors (Lin-CD29loCD24+CD61+) are increased in 6 week old mice

abnormal mammary gland duct morphology ( J:187299 )

• mammary gland ducts are dilated at both 6 and 12 weeks of age and the majority at 12 weeks are enlarged and show areas of multilayered epithelium which is hyperplastic in some regions and shows presence of an eosinophilic luminal secretion

• 13 month old nulliparous and biparous mice show enlarged ducts, particularly in the nipple region of the biparous mice and small focal lesions

• mammary glands of aged mice have ectatic ducts filled with eosinophilic luminal secretions

abnormal branching of the mammary ductal tree ( J:187299 )

• mice show increased secondary and tertiary branching at 12 weeks of age

abnormal mammary duct terminal end bud morphology ( J:187299 )

• mice show increased number and size of invading mammary gland terminal end buds at 6 weeks

• increase in proliferation within the terminal end buds

abnormal mammary gland myoepithelium morphology ( J:187299 )

• anaplasia of basal cells in the mammary gland

• colony forming ability of the stem cell enriched basal population is enhanced

abnormal mammary gland stroma morphology ( J:187299 )

• ducts are surrounded by an increase in the number of stromal cells

increased mammary gland tumor incidence ( J:187299 )

• nulliparous and biparous mice over 12 months of age develop mammary gland tumors, with tumor formation accelerated in biparous mice

• however, no metastasis is seen

increased fibroadenoma incidence ( J:187299 )

• 45% of tumors are benign fibroadenomas

increased mammary adenoacanthoma incidence ( J:187299 )

• 10% of mammary tumors are adenosquamous carcinomas

cellular

increased mammary gland epithelial cell proliferation ( J:187299 )

• increase in proliferation within the multilayered epithelia of the mammary ducts

• colony forming ability of the luminal progenitors is enhanced

integument

increased mammary gland epithelial cell proliferation ( J:187299 )

• increase in proliferation within the multilayered epithelia of the mammary ducts

• colony forming ability of the luminal progenitors is enhanced

abnormal mammary gland epithelium morphology ( J:187299 )

• loss of polarity in the mammary gland epithelium

• the luminal cell population (Lin-CD29loCD24+) and luminal progenitors (Lin-CD29loCD24+CD61+) are increased in 6 week old mice

abnormal mammary gland duct morphology ( J:187299 )

• 13 month old nulliparous and biparous mice show enlarged ducts, particularly in the nipple region of the biparous mice and small focal lesions

• mammary glands of aged mice have ectatic ducts filled with eosinophilic luminal secretions

abnormal branching of the mammary ductal tree ( J:187299 )

• mice show increased secondary and tertiary branching at 12 weeks of age

abnormal mammary duct terminal end bud morphology ( J:187299 )

• mice show increased number and size of invading mammary gland terminal end buds at 6 weeks

• increase in proliferation within the terminal end buds

abnormal mammary gland myoepithelium morphology ( J:187299 )

• anaplasia of basal cells in the mammary gland

• colony forming ability of the stem cell enriched basal population is enhanced

abnormal mammary gland stroma morphology ( J:187299 )

• ducts are surrounded by an increase in the number of stromal cells

increased mammary gland tumor incidence ( J:187299 )

• nulliparous and biparous mice over 12 months of age develop mammary gland tumors, with tumor formation accelerated in biparous mice

• however, no metastasis is seen

increased fibroadenoma incidence ( J:187299 )

• 45% of tumors are benign fibroadenomas

increased mammary adenoacanthoma incidence ( J:187299 )

• 10% of mammary tumors are adenosquamous carcinomas

skeleton

increased osteosarcoma incidence ( J:187299 )

• 2.5% of tumors are osteosarcoma

neoplasm

increased mammary gland tumor incidence ( J:187299 )

• nulliparous and biparous mice over 12 months of age develop mammary gland tumors, with tumor formation accelerated in biparous mice

• however, no metastasis is seen

increased fibroadenoma incidence ( J:187299 )

• 45% of tumors are benign fibroadenomas

increased mammary adenoacanthoma incidence ( J:187299 )

• 10% of mammary tumors are adenosquamous carcinomas

increased sarcoma incidence ( J:187299 )

• 42.5% of mammary tumors are carcinosarcomas or sarcomas

increased osteosarcoma incidence ( J:187299 )

• 2.5% of tumors are osteosarcoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:187299

Allelic Composition	Stat1^tm1Mam/Stat1^tm1Mam Tg(MMTV-cre)#Mam/0
Genetic Background	involves: 129S/SvEv * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1^tm1Mam mutation (1 available); any Stat1 mutation (74 available)
Tg(MMTV-cre)#Mam mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:169262 )

N	• female mice exhibit normal lactation

Allelic Composition	Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi} Tg(MMTV-cre)#Mam/0 Tg(MMTV-PyVT)634Mul/0
Genetic Background	involves: C57BL/6N * FVB * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddr2^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Ddr2 mutation (61 available)
Tg(MMTV-cre)#Mam mutation (0 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:236031 )

• mice show a similar primary mammary gland tumor growth and tumor burden as single Tg(MMTV-PyVT)634Mul/0 mice, no differences in the number of lung metastases, and similar levels of fibrillar collagen in tumors

integument

increased mammary gland tumor incidence ( J:236031 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:236031 )

Allelic Composition	Chek1^tm2.1Sje/Chek1⁺ Tg(MMTV-cre)#Mam/0
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1^tm2.1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(MMTV-cre)#Mam mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:162126 )

N	• mice do not develop mammary gland tumors

endocrine/exocrine glands

abnormal mammary gland morphology ( J:162126 )

• at 2 to 12 months, mammary glands are less dense than in wild-type mice

abnormal mammary gland alveolus morphology ( J:162126 )

• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

integument

abnormal mammary gland morphology ( J:162126 )

• at 2 to 12 months, mammary glands are less dense than in wild-type mice

abnormal mammary gland alveolus morphology ( J:162126 )

• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

Allelic Composition	Chek1^tm2.1Sje/Chek1^tm2.1Sje Tg(MMTV-cre)#Mam/0
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1^tm2.1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(MMTV-cre)#Mam mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:162126 )

N	• mice do not develop mammary gland tumors

endocrine/exocrine glands

abnormal mammary gland morphology ( J:162126 )

• at 2 to 12 months, mammary glands are less dense than in wild-type mice

abnormal mammary gland alveolus morphology ( J:162126 )

• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

integument

abnormal mammary gland morphology ( J:162126 )

• at 2 to 12 months, mammary glands are less dense than in wild-type mice

abnormal mammary gland alveolus morphology ( J:162126 )

• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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