All Phenotypes Tg(IGH@*)SALed MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(IGH@*)SALed
transgene insertion SA, Philip Leder
MGI:3802806

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Igh-J^tm1Jkbv/Igh-J^tm1Jkbv Tg(IGH@*)SALed/0	involves: 129P2/OlaHsd	MGI:3802928
tg2	Tg(IGH@*)SALed/0	involves: C57BL/6 * CD-1	MGI:3802833

Allelic Composition	Igh-J^tm1Jkbv/Igh-J^tm1Jkbv Tg(IGH@*)SALed/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-J^tm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Tg(IGH@*)SALed mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:137738 )

N	• the presence of the transgene prevents the arrest in B cell differentiation that occurs in Igh-J^tm1Jkbv homozygotes

decreased mature B cell number ( J:137738 )

• the levels of mature B cells found in the spleen are 50% and 70% respectively, of those found in wild-type mice

• these B cells express human mu heavy chain

hematopoietic system

decreased mature B cell number ( J:137738 )

• the levels of mature B cells found in the spleen are 50% and 70% respectively, of those found in wild-type mice

• these B cells express human mu heavy chain

Allelic Composition	Tg(IGH@*)SALed/0
Genetic Background	involves: C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal mature B cell morphology ( J:131938 )

• 25% to 35% of spleen cells express human mu heavy chain

• the proportion of spleen cells expressing endogenous mouse mu heavy chain is reduced from 50% in normal littermates to 5% to 15% in transgenic mice

• co-expression of the human transgene and endogenous murine mu heavy chain does not occur

immune system

abnormal mature B cell morphology ( J:131938 )

• 25% to 35% of spleen cells express human mu heavy chain

• the proportion of spleen cells expressing endogenous mouse mu heavy chain is reduced from 50% in normal littermates to 5% to 15% in transgenic mice

• co-expression of the human transgene and endogenous murine mu heavy chain does not occur

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