All Phenotypes Hbb<tm4(HBB*)Tow> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hbb^tm4(HBB*)Tow
targeted mutation 4, Timothy Townes
MGI:3802947

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hba^tm1(HBA)Tow/Hba^tm1(HBA)Tow Hbb^tm4(HBB)Tow/Hbb^tm4(HBB)Tow	Not Specified	MGI:3803749

Allelic Composition	Hba^tm1(HBA)Tow/Hba^tm1(HBA)Tow Hbb^tm4(HBB)Tow/Hbb^tm4(HBB)Tow
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba^tm1(HBA)Tow mutation (3 available); any Hba mutation (10 available)
Hbb^tm4(HBB*)Tow mutation (0 available); any Hbb mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

anemia ( J:137709 )

• slightly thalassemic

abnormal erythrocyte physiology ( J:137709 )

• modest but significant increase in erythrocyte oxygen affinity

cardiovascular system

cardiovascular system phenotype ( J:137709 )

N	• despite the absence of S-nitrosohemoglobin no signs of pulmonary hypertension or changes in hypoxic vasodilation response are seen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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