Phenotypes associated with this allele

• Allele Symbol: Del(10Prtn3-Elane)1Deje
• Allele Name: Deletion, Chr 10, Dieter E Jenne 1
• Allele ID: MGI:3803339
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(10Prtn3-Elane)1Deje/Del(10Prtn3-Elane)1Deje	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ	MGI:3804491

Genotype
MGI:3804491

hm1

• Allelic Composition: Del(10Prtn3-Elane)1Deje/Del(10Prtn3-Elane)1Deje
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:137674 )

N • despite the absence of 2 serine proteases no changes in neutrophil morphology, peripheral blood populations, transmigration, or chemotactic migration are detected

abnormal neutrophil physiology ( J:137674 )

• reactive oxygen species production is reduced by 30% - 40% in TNF-primed neutrophils in the presence of immune complexes

• however, oxidative burst in response to phorbol 12-myristate 13-acetate (PMA) is not different from controls

impaired neutrophil recruitment ( J:137674 )

• in the reverse passive Arthus reaction model of immune complex-mediated inflammation neutrophil infiltration and influx to sites of immune complex formation is significantly reduced

• impairment is more severe than in mice homozygous null for Ela2 only

hematopoietic system

abnormal neutrophil physiology ( J:137674 )

• reactive oxygen species production is reduced by 30% - 40% in TNF-primed neutrophils in the presence of immune complexes

• however, oxidative burst in response to phorbol 12-myristate 13-acetate (PMA) is not different from controls

impaired neutrophil recruitment ( J:137674 )

• in the reverse passive Arthus reaction model of immune complex-mediated inflammation neutrophil infiltration and influx to sites of immune complex formation is significantly reduced

• impairment is more severe than in mice homozygous null for Ela2 only