Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^tm2(Pax3)Joe
• Allele Name: targeted mutation 2, Jonathan A Epstein
• Allele ID: MGI:3803568
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gt(ROSA)26Sor^tm2(Pax3)Joe/Gt(ROSA)26Sor^tm2(Pax3)Joe	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3804313
cn2	Gt(ROSA)26Sor^tm2(Pax3)Joe/Gt(ROSA)26Sor^tm2(Pax3)Joe Pax3^tm1(cre)Joe/Pax3^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3804314
cn3	Gt(ROSA)26Sor^tm2(Pax3)Joe/Gt(ROSA)26Sor^tm2(Pax3)Joe Pax3^tm1(cre)Joe/Pax3^tm1(cre)Joe	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3804316
cn4	Gt(ROSA)26Sor^tm2(Pax3)Joe/Gt(ROSA)26Sor^+ Pax3^tm1(cre)Joe/Pax3^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3804317
cn5	Gt(ROSA)26Sor^tm2(Pax3)Joe/Gt(ROSA)26Sor^tm2(Pax3)Joe H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3804318
cn6	Gt(ROSA)26Sor^tm2(Pax3)Joe/Gt(ROSA)26Sor^+ H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3804321

Genotype
MGI:3804313

hm1

• Allelic Composition: Gt(ROSA)26Sor^tm2(Pax3)Joe/Gt(ROSA)26Sor^tm2(Pax3)Joe
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:137730 )

• mice appear normal

Genotype
MGI:3804314

cn2

• Allelic Composition: Gt(ROSA)26Sor^tm2(Pax3)Joe/Gt(ROSA)26Sor^tm2(Pax3)Joe; Pax3^tm1(cre)Joe/Pax3⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

postnatal lethality ( J:137730 )

• despite normal numbers at E17.5, no mice survive beyond P2 due to a failure to suckle

craniofacial

abnormal craniofacial bone morphology ( J:137730 )

absent alisphenoid bone ( J:137730 )

• the alisphenoid is hypoplastic or absent

alisphenoid bone hypoplasia ( J:137730 )

• the alisphenoid is hypoplastic or absent

abnormal pterygoid process morphology ( J:137730 )

• the pterygoid process is hypoplastic or absent

absent pterygoid process ( J:137730 )

• the pterygoid process is hypoplastic or absent

abnormal secondary palate development ( J:137730 )

• at P0, the secondary palate is absent

• at E14.5 and E16.5, mice lack ossification centers along the midline of the palate

• at E15.5 and E17.5, mineralization of the palate is decreased

cleft palate ( J:137730 )

failure of palatal shelf elevation ( J:137730 )

• at E16.5, mutant mice display a cleft palate with palatal shelves that fail to lift

skeleton

abnormal osteoblast differentiation ( J:137730 )

• impaired in primary palate cultures

abnormal craniofacial bone morphology ( J:137730 )

absent alisphenoid bone ( J:137730 )

• the alisphenoid is hypoplastic or absent

alisphenoid bone hypoplasia ( J:137730 )

• the alisphenoid is hypoplastic or absent

abnormal pterygoid process morphology ( J:137730 )

• the pterygoid process is hypoplastic or absent

absent pterygoid process ( J:137730 )

• the pterygoid process is hypoplastic or absent

abnormal bone ossification ( J:137730 )

• primary palate cultures fail to form nodules and mineralize following treatment with BMP unlike in wild-type cultures due to impaired osteogenic differentiation

abnormal bone mineralization ( J:137730 )

• at E14.5 and E16.5, mice lack ossification centers along the midline of the palate

• at E15.5 and E17.5, mineralization of the palate is decreased

limbs/digits/tail

limbs/digits/tail phenotype ( J:137730 )

N • unlike Pax3^tm1(cre)Joe homozygotes, hindlimb development is normal

abnormal forelimb morphology ( J:137730 )

• forelimb musculature is hypoplastic

vision/eye

abnormal eyelid development ( J:137730 )

• mice exhibit defects in eyelid development from eyelids that fail to fuse to completely missing eyelids

failure of eyelid fusion ( J:137730 )

• in some mice

absent eyelids ( J:137730 )

• in some mice

hearing/vestibular/ear

decreased tympanic ring size ( J:137730 )

• thinned

muscle

muscle phenotype ( J:137730 )

N • unlike Pax3^tm1(cre)Joe homozygotes, diaphragm and hindlimb musculature develop normally

hypaxial muscle hypoplasia ( J:137730 )

• forelimb musculature is hypoplastic

nervous system

nervous system phenotype ( J:137730 )

N • unlike Pax3^tm1(cre)Joe homozygotes, mice exhibit normal neural tube development

digestive/alimentary system

abnormal secondary palate development ( J:137730 )

• at P0, the secondary palate is absent

• at E14.5 and E16.5, mice lack ossification centers along the midline of the palate

• at E15.5 and E17.5, mineralization of the palate is decreased

cleft palate ( J:137730 )

failure of palatal shelf elevation ( J:137730 )

• at E16.5, mutant mice display a cleft palate with palatal shelves that fail to lift

cellular

abnormal osteoblast differentiation ( J:137730 )

• impaired in primary palate cultures

growth/size/body

abnormal secondary palate development ( J:137730 )

• at P0, the secondary palate is absent

• at E14.5 and E16.5, mice lack ossification centers along the midline of the palate

• at E15.5 and E17.5, mineralization of the palate is decreased

cleft palate ( J:137730 )

failure of palatal shelf elevation ( J:137730 )

• at E16.5, mutant mice display a cleft palate with palatal shelves that fail to lift

Genotype
MGI:3804316

cn3

• Allelic Composition: Gt(ROSA)26Sor^tm2(Pax3)Joe/Gt(ROSA)26Sor^tm2(Pax3)Joe; Pax3^tm1(cre)Joe/Pax3^tm1(cre)Joe
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

postnatal lethality ( J:137730 )

• despite normal numbers at E17.5, no mice survive beyond P2

Genotype
MGI:3804317

cn4

• Allelic Composition: Gt(ROSA)26Sor^tm2(Pax3)Joe/Gt(ROSA)26Sor⁺; Pax3^tm1(cre)Joe/Pax3⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

craniofacial

decreased palatal length ( J:137730 )

• mice display mild shortening of the palate

limbs/digits/tail

limbs/digits/tail phenotype ( J:137730 )

N • unlike Pax3^tm1(cre)Joe homozygotes, hind limb morphology is normal

muscle

muscle phenotype ( J:137730 )

N • unlike Pax3^tm1(cre)Joe homozygotes, diaphragm morphology is normal

digestive/alimentary system

decreased palatal length ( J:137730 )

• mice display mild shortening of the palate

growth/size/body

decreased palatal length ( J:137730 )

• mice display mild shortening of the palate

Genotype
MGI:3804318

cn5

• Allelic Composition: Gt(ROSA)26Sor^tm2(Pax3)Joe/Gt(ROSA)26Sor^tm2(Pax3)Joe; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

craniofacial

abnormal craniofacial morphology ( J:137730 )

• authors state that mice exhibit identical phenotypes as observed in Gt(ROSA)26Sor^tm2Joe/Gt(ROSA)26Sor^tm2Joe Pax3^tm1(cre)Joe/Pax3⁺ mice

abnormal palate morphology ( J:137730 )

• authors state that mice exhibit identical phenotypes as observed in Gt(ROSA)26Sor^tm2Joe/Gt(ROSA)26Sor^tm2Joe Pax3^tm1(cre)Joe/Pax3⁺ mice

vision/eye

abnormal eyelid morphology ( J:137730 )

• authors state that mice exhibit identical phenotypes as observed in Gt(ROSA)26Sor^tm2Joe/Gt(ROSA)26Sor^tm2Joe Pax3^tm1(cre)Joe/Pax3⁺ mice

digestive/alimentary system

abnormal palate morphology ( J:137730 )

• authors state that mice exhibit identical phenotypes as observed in Gt(ROSA)26Sor^tm2Joe/Gt(ROSA)26Sor^tm2Joe Pax3^tm1(cre)Joe/Pax3⁺ mice

growth/size/body

abnormal palate morphology ( J:137730 )

• authors state that mice exhibit identical phenotypes as observed in Gt(ROSA)26Sor^tm2Joe/Gt(ROSA)26Sor^tm2Joe Pax3^tm1(cre)Joe/Pax3⁺ mice

Genotype
MGI:3804321

cn6

• Allelic Composition: Gt(ROSA)26Sor^tm2(Pax3)Joe/Gt(ROSA)26Sor⁺; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

craniofacial

cleft palate ( J:137730 )

• in one mouse

digestive/alimentary system

cleft palate ( J:137730 )

• in one mouse

growth/size/body

cleft palate ( J:137730 )

• in one mouse