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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcf3tm1Mbu
targeted mutation 1, Meinrad Busslinger
MGI:3803637
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ikzf1tm1.1(Pax5)Mbu/Ikzf1+
Tcf3tm1Mbu/Tcf3tm1Mbu
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca MGI:3804204
cn2
 		Tcf3tm1Mbu/Tcf3tm1Mbu
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca MGI:3804186
cn3
 		Cd19tm1(cre)Cgn/Cd19+
Tcf3tm1Mbu/Tcf3tm1.2Mbu
Tg(Vav-BCL2)69Jad/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL MGI:3804187
cn4
 		Tcf3tm1Mbu/Tcf3tm1.2Mbu
Tg(Aicda-cre)9Mbu/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:3804202
cn5
 		Tcf3tm1Mbu/Tcf3tm1.2Mbu
Tg(Fcer2a-cre)5Mbu/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:3804199
cn6
 		Cd19tm1(cre)Cgn/Cd19+
Tcf3tm1Mbu/Tcf3tm1.2Mbu 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3804190
cn7
 		Tcf3tm1Mbu/Tcf3tm1Mbu
Tg(Ikzf1-Tcfe2a,-GFP)1Mbu/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: 129P2/OlaHsd * C57BL * CBA MGI:3804203


Genotype
MGI:3804204
cn1
Allelic
Composition		 Ikzf1tm1.1(Pax5)Mbu/Ikzf1+
Tcf3tm1Mbu/Tcf3tm1Mbu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Ikzf1tm1.1(Pax5)Mbu mutation (0 available); any Ikzf1 mutation (30 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:137719 )
N
• development of pro-B cells is rescued
abnormal immunoglobulin heavy chain V(D)J recombination ( J:137719 )
• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice
• Vk-Jk recombination of the Igk locus is absent

hematopoietic system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:137719 )
• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice
• Vk-Jk recombination of the Igk locus is absent




Genotype
MGI:3804186
cn2
Allelic
Composition		 Tcf3tm1Mbu/Tcf3tm1Mbu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased pro-B cell number ( J:137719 )
• mice lack committed c-Kit+CD19+ pro-B cells

immune system
decreased pro-B cell number ( J:137719 )
• mice lack committed c-Kit+CD19+ pro-B cells




Genotype
MGI:3804187
cn3
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Tcf3tm1Mbu/Tcf3tm1.2Mbu
Tg(Vav-BCL2)69Jad/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Tcf3tm1.2Mbu mutation (0 available); any Tcf3 mutation (43 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (43 available)
Tg(Vav-BCL2)69Jad mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased pre-B cell number ( J:137719 )
• GFP+ pre-B cells are absent in the bone marrow

immune system
decreased pre-B cell number ( J:137719 )
• GFP+ pre-B cells are absent in the bone marrow




Genotype
MGI:3804202
cn4
Allelic
Composition		 Tcf3tm1Mbu/Tcf3tm1.2Mbu
Tg(Aicda-cre)9Mbu/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1.2Mbu mutation (0 available); any Tcf3 mutation (43 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (43 available)
Tg(Aicda-cre)9Mbu mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:137719 )
N
• despite reduced B cell numbers, class switching and B cell proliferation following stimulation are normal following immunization
decreased B cell number ( J:137719 )
• following immunization, the number of IgG2a- and IgG3-secreting cells is decreased compared to in wild-type mice
abnormal germinal center B cell morphology ( J:137719 )
• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
decreased germinal center B cell number ( J:137719 )
• at day 4 following immunization, the number of germinal cell B cells in the spleen is reduced and remains 7- to 4-fold lower at day 8 and 12 compared to in wild-type and heterozygous mice

hematopoietic system
decreased B cell number ( J:137719 )
• following immunization, the number of IgG2a- and IgG3-secreting cells is decreased compared to in wild-type mice
decreased germinal center B cell number ( J:137719 )
• at day 4 following immunization, the number of germinal cell B cells in the spleen is reduced and remains 7- to 4-fold lower at day 8 and 12 compared to in wild-type and heterozygous mice
abnormal germinal center B cell morphology ( J:137719 )
• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal




Genotype
MGI:3804199
cn5
Allelic
Composition		 Tcf3tm1Mbu/Tcf3tm1.2Mbu
Tg(Fcer2a-cre)5Mbu/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1.2Mbu mutation (0 available); any Tcf3 mutation (43 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (43 available)
Tg(Fcer2a-cre)5Mbu mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:137719 )
N
• despite reduced B cell numbers, class switching, NP-specific production of IgG1, IgG2a and IgG3, B cell proliferation, memory B cells and plasma B cells following stimulation are normal following immunization
decreased B cell number ( J:137719 )
• splenic B cell numbers are minimally reduced compared to in wild-type mice
abnormal germinal center B cell morphology ( J:137719 )
• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
decreased germinal center B cell number ( J:137719 )
• at 4 and 8 days after immunization germinal center B cell numbers are 3- to 5-fold lower tan in wild-type or heterozygous mice

hematopoietic system
decreased B cell number ( J:137719 )
• splenic B cell numbers are minimally reduced compared to in wild-type mice
decreased germinal center B cell number ( J:137719 )
• at 4 and 8 days after immunization germinal center B cell numbers are 3- to 5-fold lower tan in wild-type or heterozygous mice
abnormal germinal center B cell morphology ( J:137719 )
• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal




Genotype
MGI:3804190
cn6
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Tcf3tm1Mbu/Tcf3tm1.2Mbu
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Tcf3tm1.2Mbu mutation (0 available); any Tcf3 mutation (43 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased pro-B cell number ( J:137719 )
• in the bone marrow, pro-B and re-circulating B cell numbers are decreased by half compared to in wild-type mice
decreased B cell number ( J:137719 )
• in the bone marrow, total B cell number in the bone marrow is reduced to 30% of wild-type
• the spleen contains half the number of B cells as in wild-type mice
decreased immature B cell number ( J:137719 )
• in the bone marrow, immature B cells are decreased to 18% of wild-type numbers
• in the spleen, immature B cells are reduced by 50% compared to in wild-type mice
decreased transitional stage B cell number ( J:137719 )
• in the spleen, transitional B cells are reduced by 50% compared to in wild-type mice
decreased mature B cell number ( J:137719 )
• in the spleen, mature B cells are reduced by 50% compared to in wild-type mice
decreased pre-B cell number ( J:137719 )
• in the bone marrow, pre-B cells are decreased to 18% of wild-type numbers
• GFP+ pre-B cells are absent in the bone marrow

hematopoietic system
decreased pro-B cell number ( J:137719 )
• in the bone marrow, pro-B and re-circulating B cell numbers are decreased by half compared to in wild-type mice
decreased B cell number ( J:137719 )
• in the bone marrow, total B cell number in the bone marrow is reduced to 30% of wild-type
• the spleen contains half the number of B cells as in wild-type mice
decreased immature B cell number ( J:137719 )
• in the bone marrow, immature B cells are decreased to 18% of wild-type numbers
• in the spleen, immature B cells are reduced by 50% compared to in wild-type mice
decreased transitional stage B cell number ( J:137719 )
• in the spleen, transitional B cells are reduced by 50% compared to in wild-type mice
decreased mature B cell number ( J:137719 )
• in the spleen, mature B cells are reduced by 50% compared to in wild-type mice
decreased pre-B cell number ( J:137719 )
• in the bone marrow, pre-B cells are decreased to 18% of wild-type numbers
• GFP+ pre-B cells are absent in the bone marrow




Genotype
MGI:3804203
cn7
Allelic
Composition		 Tcf3tm1Mbu/Tcf3tm1Mbu
Tg(Ikzf1-Tcfe2a,-GFP)1Mbu/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (43 available)
Tg(Ikzf1-Tcfe2a,-GFP)1Mbu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:137719 )
N
• c-Kit+B220+ pro-B cells and c-Kit-B220+ developmental stages are rescued




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory