Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tcf3tm1.2Mbu targeted mutation 1.2, Meinrad Busslinger MGI:3803639 |
||||||||||||||||||||
| Summary |
4 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• GFP+ pre-B cells are absent in the bone marrow
|
|
• GFP+ pre-B cells are absent in the bone marrow
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• despite reduced B cell numbers, class switching, NP-specific production of IgG1, IgG2a and IgG3, B cell proliferation, memory B cells and plasma B cells following stimulation are normal following immunization
|
|
• slight
|
|
• splenic B cell numbers are minimally reduced compared to in wild-type mice
|
|
• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
|
|
• at 4 and 8 days after immunization germinal center B cell numbers are 3- to 5-fold lower tan in wild-type or heterozygous mice
|
|
• slight
|
|
• splenic B cell numbers are minimally reduced compared to in wild-type mice
|
|
• at 4 and 8 days after immunization germinal center B cell numbers are 3- to 5-fold lower tan in wild-type or heterozygous mice
|
|
• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• despite reduced B cell numbers, class switching and B cell proliferation following stimulation are normal following immunization
|
|
• following immunization, the number of IgG2a- and IgG3-secreting cells is decreased compared to in wild-type mice
|
|
• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
|
|
• at day 4 following immunization, the number of germinal cell B cells in the spleen is reduced and remains 7- to 4-fold lower at day 8 and 12 compared to in wild-type and heterozygous mice
|
|
• following immunization, the number of IgG2a- and IgG3-secreting cells is decreased compared to in wild-type mice
|
|
• at day 4 following immunization, the number of germinal cell B cells in the spleen is reduced and remains 7- to 4-fold lower at day 8 and 12 compared to in wild-type and heterozygous mice
|
|
• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• in the bone marrow, pro-B and re-circulating B cell numbers are decreased by half compared to in wild-type mice
|
|
• in the bone marrow, total B cell number in the bone marrow is reduced to 30% of wild-type
• the spleen contains half the number of B cells as in wild-type mice
|
|
• in the bone marrow, immature B cells are decreased to 18% of wild-type numbers
• in the spleen, immature B cells are reduced by 50% compared to in wild-type mice
|
|
• in the spleen, transitional B cells are reduced by 50% compared to in wild-type mice
|
|
• in the spleen, mature B cells are reduced by 50% compared to in wild-type mice
|
|
• in the bone marrow, pre-B cells are decreased to 18% of wild-type numbers
• GFP+ pre-B cells are absent in the bone marrow
|
|
• in the bone marrow, pro-B and re-circulating B cell numbers are decreased by half compared to in wild-type mice
|
|
• in the bone marrow, total B cell number in the bone marrow is reduced to 30% of wild-type
• the spleen contains half the number of B cells as in wild-type mice
|
|
• in the bone marrow, immature B cells are decreased to 18% of wild-type numbers
• in the spleen, immature B cells are reduced by 50% compared to in wild-type mice
|
|
• in the spleen, transitional B cells are reduced by 50% compared to in wild-type mice
|
|
• in the spleen, mature B cells are reduced by 50% compared to in wild-type mice
|
|
• in the bone marrow, pre-B cells are decreased to 18% of wild-type numbers
• GFP+ pre-B cells are absent in the bone marrow
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/19/2024 MGI 6.24 |
|
|
|
||
