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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Aicda-cre)9Mbu
transgene insertion 9, Meinrad Busslinger
MGI:3803651
Summary 4 genotypes


Genotype
MGI:4840319
cn1
Allelic
Composition		 Bcl2l1tm1Dlo/Bcl2l1tm1.1Mam
Tg(Aicda-cre)9Mbu/0
Genetic
Background		 B6.Cg-Bcl2l1tm1Dlo/Bcl2l1tm1.1Mam Tg(Aicda-cre)9Mbu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1.1Mam mutation (0 available); any Bcl2l1 mutation (104 available)
Bcl2l1tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)
Tg(Aicda-cre)9Mbu mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:166069 )
N
• affinity maturation among NP-reactive B cells and germinal cell formation are normal
decreased IgG1 level ( J:166069 )
• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the bone marrow compared to in similarly treated wild-type mice

hematopoietic system
decreased IgG1 level ( J:166069 )
• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the bone marrow compared to in similarly treated wild-type mice




Genotype
MGI:4840315
cn2
Allelic
Composition		 Mcl1tm1Dmta/Mcl1tm1Dmta
Tg(Aicda-cre)9Mbu/0
Genetic
Background		 B6.Cg-Mcl1tm1Dmta Tg(Aicda-cre)9Mbu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm1Dmta mutation (0 available); any Mcl1 mutation (35 available)
Tg(Aicda-cre)9Mbu mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:166069 )
N
• affinity maturation among NP-reactive B cells is normal
absent germinal center B cells ( J:166069 )
• following immunization with NP-KLH
absent memory B cells ( J:166069 )
• following immunization with NP-KLH
decreased IgG1 level ( J:166069 )
• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the serum, spleen and bone marrow compared to in similarly treated wild-type mice

hematopoietic system
absent germinal center B cells ( J:166069 )
• following immunization with NP-KLH
absent memory B cells ( J:166069 )
• following immunization with NP-KLH
decreased IgG1 level ( J:166069 )
• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the serum, spleen and bone marrow compared to in similarly treated wild-type mice




Genotype
MGI:4840316
cn3
Allelic
Composition		 Mcl1tm1Dmta/Mcl1+
Tg(Aicda-cre)9Mbu/0
Genetic
Background		 B6.Cg-Mcl1tm1Dmta Tg(Aicda-cre)9Mbu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm1Dmta mutation (0 available); any Mcl1 mutation (35 available)
Tg(Aicda-cre)9Mbu mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased germinal center B cell number ( J:166069 )
• following immunization with NP-KLH
decreased memory B cell number ( J:166069 )
• following immunization with NP-KLH

hematopoietic system
decreased germinal center B cell number ( J:166069 )
• following immunization with NP-KLH
decreased memory B cell number ( J:166069 )
• following immunization with NP-KLH




Genotype
MGI:3804202
cn4
Allelic
Composition		 Tcf3tm1Mbu/Tcf3tm1.2Mbu
Tg(Aicda-cre)9Mbu/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1.2Mbu mutation (0 available); any Tcf3 mutation (43 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (43 available)
Tg(Aicda-cre)9Mbu mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:137719 )
N
• despite reduced B cell numbers, class switching and B cell proliferation following stimulation are normal following immunization
decreased B cell number ( J:137719 )
• following immunization, the number of IgG2a- and IgG3-secreting cells is decreased compared to in wild-type mice
abnormal germinal center B cell morphology ( J:137719 )
• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
decreased germinal center B cell number ( J:137719 )
• at day 4 following immunization, the number of germinal cell B cells in the spleen is reduced and remains 7- to 4-fold lower at day 8 and 12 compared to in wild-type and heterozygous mice

hematopoietic system
decreased B cell number ( J:137719 )
• following immunization, the number of IgG2a- and IgG3-secreting cells is decreased compared to in wild-type mice
decreased germinal center B cell number ( J:137719 )
• at day 4 following immunization, the number of germinal cell B cells in the spleen is reduced and remains 7- to 4-fold lower at day 8 and 12 compared to in wild-type and heterozygous mice
abnormal germinal center B cell morphology ( J:137719 )
• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory