Phenotypes associated with this allele

• Allele Symbol: Fasl^del1Hong
• Allele Name: deletion 1, Wanjin Hong
• Allele ID: MGI:3803664
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fasl^del1Hong/Fasl^del1Hong	either: (involves: 129 * BALB/c * C57BL/6) or (involves: 129X1/SvJ * C3H/HeJ * C57BL/6)	MGI:3803710

Genotype
MGI:3803710

hm1

• Allelic Composition: Fasl^del1Hong/Fasl^del1Hong
• Genetic Background: either: (involves: 129 * BALB/c * C57BL/6) or (involves: 129X1/SvJ * C3H/HeJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:112563 )

• >50% of affected mice die by 4 months of age; few animals survive beyond 1 year

neoplasm

increased metastatic potential ( J:112563 )

• lymphomas spread to non-lymphoid organs in older mice

• Background Sensitivity: lymphoma cell infiltration of lungs and liver is more severe on BALB/c background than on 129S1/SvJ or C3H/HeJ backgrounds

• spread of lymphoma cells to kidney or ovary is sometimes observed

increased lymphoma incidence ( J:112563 )

• all mice develop lymphoma

immune system

abnormal thymus cell ratio ( J:112563 )

• majority of thymocytes in aged mice are CD4-CD8-CD3+B220+

enlarged thymus ( J:112563 )

• at end of third month, thymi in affected mice start to grow with some thymi weighing >1 gram at 5-6 months

enlarged spleen ( J:112563 )

• severe; obvious from 6 weeks; in 5-month old affected mice, spleens are 10-20 fold larger than wild-type

increased IgG level ( J:112563 )

• mice exhibit hypergammaglobulinemia with 12-fold higher serum levels than wild-type

• significant IgG deposits observed in glomeruli

increased IgM level ( J:112563 )

• IgM levels are increased about 8-fold in serum

enlarged lymph nodes ( J:112563 )

• enlarged cervical lymph nodes are visible by 9-10 weeks

hematopoietic system

abnormal thymus cell ratio ( J:112563 )

• majority of thymocytes in aged mice are CD4-CD8-CD3+B220+

enlarged thymus ( J:112563 )

• at end of third month, thymi in affected mice start to grow with some thymi weighing >1 gram at 5-6 months

enlarged spleen ( J:112563 )

• severe; obvious from 6 weeks; in 5-month old affected mice, spleens are 10-20 fold larger than wild-type

abnormal definitive hematopoiesis ( J:112563 )

• leukocyte population that is TCR+CD3+B220+CD19-CD4-CD8- increases from 5% of total splenocytes to >70% at 5 months

increased IgG level ( J:112563 )

• mice exhibit hypergammaglobulinemia with 12-fold higher serum levels than wild-type

• significant IgG deposits observed in glomeruli

increased IgM level ( J:112563 )

• IgM levels are increased about 8-fold in serum

endocrine/exocrine glands

abnormal thymus cell ratio ( J:112563 )

• majority of thymocytes in aged mice are CD4-CD8-CD3+B220+

enlarged thymus ( J:112563 )

• at end of third month, thymi in affected mice start to grow with some thymi weighing >1 gram at 5-6 months

growth/size/body

enlarged spleen ( J:112563 )

• severe; obvious from 6 weeks; in 5-month old affected mice, spleens are 10-20 fold larger than wild-type