Analysis Tools
nervous system
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• stellate axons appear thinner, more wavy, with significantly altered orientation and trajectories compared to controls at P40
• stellate axons display reduced association with Bergmann glial fibers and a reduction of vertically oriented branches
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• at P44, density of symmetric synapses at Purkinje dendrites is reduced by 60%; density of symmetric synapses at Purkinje dendrites is reduced by 40% at P30
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• stellate axons appear thinner, more wavy, with significantly altered orientation and trajectories compared to controls at P40
• stellate axons display reduced association with Bergmann glial (BG) fibers and a reduction of vertically oriented branches, with >30% of stellate axon branches associated with BG fibers; this is apparent at P16 and P20
• basket axons and their innervation of Purkinje cells appears normal
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• abnormal stellate axons have smaller boutons than wild-type
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• in upper molecular layer of the cerebellum in 3 month-old mice, degenerating axon profiles are often observed
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