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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cited2tm2Bha
targeted mutation 2, Shoumo Bhattacharya
MGI:3803778
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cited2tm1Bha/Cited2tm2Bha
Tg(T-cre)1Lwd/0 		involves: 129 * C3H * C57BL/6 * SJL MGI:3804088
cn2
 		Cited2tm1Bha/Cited2tm2Bha
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129 * C57BL/6 * CBA * SJL MGI:3804085
cn3
 		Cited2tm1Bha/Cited2tm2Bha
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129 * C57BL/6 * CBA * SJL MGI:3804086
cn4
 		Cited2tm1Bha/Cited2tm2Bha
Mesp1tm2(cre)Ysa/Mesp1+ 		involves: 129 * C57BL/6 * CBA * SJL MGI:3804087


Genotype
MGI:3804088
cn1
Allelic
Composition		 Cited2tm1Bha/Cited2tm2Bha
Tg(T-cre)1Lwd/0
Genetic
Background		 involves: 129 * C3H * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited2tm1Bha mutation (3 available); any Cited2 mutation (23 available)
Cited2tm2Bha mutation (2 available); any Cited2 mutation (23 available)
Tg(T-cre)1Lwd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:137951 )
• 3 of 14 mice exhibit defective cardiac septation and 1 of 14 mice exhibit abnormal left-right patterning
double outlet right ventricle ( J:137951 )
• both the aorta and the pulmonary trunk arise from the right ventricle
right atrial isomerism ( J:137951 )
• indicated by bilateral systemic venous sinuses and a common atrium created by complete absence of the primary atrial septum
common atrium ( J:137951 )
• common atrium created by complete absence of the primary atrial septum
dextrocardia ( J:137951 )
• in few mice
abnormal heart left ventricle morphology ( J:137951 )
• dextral left ventricle

respiratory system

endocrine/exocrine glands
absent adrenal gland ( J:137951 )
• in 10 of 14 mice

growth/size/body
right atrial isomerism ( J:137951 )
• indicated by bilateral systemic venous sinuses and a common atrium created by complete absence of the primary atrial septum
right pulmonary isomerism ( J:137951 )
• in few mice




Genotype
MGI:3804085
cn2
Allelic
Composition		 Cited2tm1Bha/Cited2tm2Bha
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited2tm1Bha mutation (3 available); any Cited2 mutation (23 available)
Cited2tm2Bha mutation (2 available); any Cited2 mutation (23 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:137951 )
• though present in Mendelian ratios at E15.5, mice die during late gestation or postnatal development with no mice present at weaning
postnatal lethality, complete penetrance ( J:137951 )
• though present in Mendelian ratios at E15.5, mice die during late gestation or postnatal development with no mice present at weaning

cardiovascular system
right aortic arch ( J:137951 )
• in some mice
abnormal inferior vena cava morphology ( J:137951 )
• bilateral in one mouse
common atrioventricular valve ( J:137951 )
• some mice exhibit a common atrioventricular valve
right atrial isomerism ( J:137951 )
• in some mice
dextrocardia ( J:137951 )
• in one mouse
ventricular septal defect ( J:137951 )
• in all embryos at E15.5
abnormal heart left ventricle morphology ( J:137951 )
• abnormal ventricular topology

respiratory system
right pulmonary isomerism ( J:137951 )
• in 6 of 10 embryos and associated with right atrial isomerism at E15.5

nervous system
exencephaly ( J:137951 )
• 2 mice at E15.5

endocrine/exocrine glands

growth/size/body
right atrial isomerism ( J:137951 )
• in some mice
right pulmonary isomerism ( J:137951 )
• in 6 of 10 embryos and associated with right atrial isomerism at E15.5




Genotype
MGI:3804086
cn3
Allelic
Composition		 Cited2tm1Bha/Cited2tm2Bha
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited2tm1Bha mutation (3 available); any Cited2 mutation (23 available)
Cited2tm2Bha mutation (2 available); any Cited2 mutation (23 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:137951 )
• despite present in Mendelian ratios at E18.5, fewer than expected survive to weaning
postnatal lethality, incomplete penetrance ( J:137951 )
• despite present in Mendelian ratios at E18.5, fewer than expected survive to weaning

nervous system
exencephaly ( J:137951 )
• in one mouse
abnormal glossopharyngeal ganglion morphology ( J:137951 )
• 11 of 14 mice exhibit fusion of ganglia IX and X
abnormal vagus ganglion morphology ( J:137951 )
• 11 of 14 mice exhibit fusion of ganglia IX and X




Genotype
MGI:3804087
cn4
Allelic
Composition		 Cited2tm1Bha/Cited2tm2Bha
Mesp1tm2(cre)Ysa/Mesp1+
Genetic
Background		 involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited2tm1Bha mutation (3 available); any Cited2 mutation (23 available)
Cited2tm2Bha mutation (2 available); any Cited2 mutation (23 available)
Mesp1tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
ventricular septal defect ( J:137951 )
• while the outflow tract and aortic arch are normal, 3 of 18 mice exhibit septal defects




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06/12/2024
MGI 6.13 		The Jackson Laboratory