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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Lck-Akt1*E40K)E-3Pnt
transgene insertion E-3, Philip N Tsichlis
MGI:3803797
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tcratm1Mom/Tcratm1Mom
Tg(Lck-Akt1*E40K)E-3Pnt/0 		involves: 129S2/SvPas * C3H/He * C57BL/6 MGI:3803976
cx2
 		Cdk6tm1Phin/Cdk6tm1Phin
Tg(Lck-Akt1*E40K)E-3Pnt/0 		involves: 129S4/SvJae MGI:3833618
cx3
 		Cdk6tm1Phin/Cdk6+
Tg(Lck-Akt1*E40K)E-3Pnt/0 		involves: 129S4/SvJae MGI:3833619
cx4
 		Rag1tm1Mom/Rag1tm1Mom
Tg(Lck-Akt1*E40K)E-3Pnt/0 		involves: 129S7/SvEvBrd * C3H/He * C57BL/6 MGI:3803975
tg5
 		Tg(Lck-Akt1*E40K)E-3Pnt/0 involves: C3H/He * C57BL/6 MGI:3803813
tg6
 		Tg(Lck-Akt1*E40K)E-3Pnt/0 Not Specified MGI:3833620


Genotype
MGI:3803976
cx1
Allelic
Composition		 Tcratm1Mom/Tcratm1Mom
Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic
Background		 involves: 129S2/SvPas * C3H/He * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mom mutation (6 available); any Tcra mutation (101 available)
Tg(Lck-Akt1*E40K)E-3Pnt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
arrested T cell differentiation ( J:135903 )
• T cell development is arrested at the double positive stage
• the presence of the transgene does not overcome this block the presence of the transgene does not overcome this block the presence of the transgene does not overcome this block

hematopoietic system
arrested T cell differentiation ( J:135903 )
• T cell development is arrested at the double positive stage
• the presence of the transgene does not overcome this block the presence of the transgene does not overcome this block the presence of the transgene does not overcome this block




Genotype
MGI:3833618
cx2
Allelic
Composition		 Cdk6tm1Phin/Cdk6tm1Phin
Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk6tm1Phin mutation (0 available); any Cdk6 mutation (40 available)
Tg(Lck-Akt1*E40K)E-3Pnt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:144975 )
N
• unlike mice with only Tg(Lck-Akt1*E40K)E-3Pnt, no thymic lymphomas develop

immune system
abnormal T cell differentiation ( J:144975 )
• the majority of DN thymocytes are DN3 unlike in wild-type mice

hematopoietic system
abnormal T cell differentiation ( J:144975 )
• the majority of DN thymocytes are DN3 unlike in wild-type mice




Genotype
MGI:3833619
cx3
Allelic
Composition		 Cdk6tm1Phin/Cdk6+
Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk6tm1Phin mutation (0 available); any Cdk6 mutation (40 available)
Tg(Lck-Akt1*E40K)E-3Pnt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:144975 )
• most mice develop tumors by 22 weeks of age and die prematurely

neoplasm
increased T cell derived lymphoma incidence ( J:144975 )
• most mice develop tumors by 22 weeks of age and die prematurely

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:144975 )
• most mice develop tumors by 22 weeks of age and die prematurely

immune system
increased T cell derived lymphoma incidence ( J:144975 )
• most mice develop tumors by 22 weeks of age and die prematurely

hematopoietic system
increased T cell derived lymphoma incidence ( J:144975 )
• most mice develop tumors by 22 weeks of age and die prematurely




Genotype
MGI:3803975
cx4
Allelic
Composition		 Rag1tm1Mom/Rag1tm1Mom
Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic
Background		 involves: 129S7/SvEvBrd * C3H/He * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(Lck-Akt1*E40K)E-3Pnt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased thymocyte number ( J:135903 )
• thymocyte numbers increase with age
increased double-positive T cell number ( J:135903 )
• 96% of thymocytes are double positive
• the presence of the transgene rescues the block of T cell development that occurs at DN3 in Rag1tm1Mom homozygotes

hematopoietic system
increased thymocyte number ( J:135903 )
• thymocyte numbers increase with age
increased double-positive T cell number ( J:135903 )
• 96% of thymocytes are double positive
• the presence of the transgene rescues the block of T cell development that occurs at DN3 in Rag1tm1Mom homozygotes

endocrine/exocrine glands
increased thymocyte number ( J:135903 )
• thymocyte numbers increase with age




Genotype
MGI:3803813
tg5
Allelic
Composition		 Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic
Background		 involves: C3H/He * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:73487 )
• about half of the mice are dead one year of age from thymic lymphomas

neoplasm
increased T cell derived lymphoma incidence ( J:73487 )
• most mice die from lymphoid neoplasms
• lymphomas contain clonal rearrangements in the T cell receptor genes lymphomas contain clonal rearrangements in the T cell receptor genes

immune system
decreased thymocyte number ( J:73487 )
• number of thymocytes is decreased by about 20% compared to wild-type mice despite the thymus having similar weight as in wild-type
• thymocyte cell size is significantly increased in these mice
increased T cell derived lymphoma incidence ( J:73487 )
• most mice die from lymphoid neoplasms
• lymphomas contain clonal rearrangements in the T cell receptor genes lymphomas contain clonal rearrangements in the T cell receptor genes
enlarged spleen ( J:73487 )
• is often observed in necropsy due to lymphomas

hematopoietic system
decreased thymocyte number ( J:73487 )
• number of thymocytes is decreased by about 20% compared to wild-type mice despite the thymus having similar weight as in wild-type
• thymocyte cell size is significantly increased in these mice
increased T cell derived lymphoma incidence ( J:73487 )
• most mice die from lymphoid neoplasms
• lymphomas contain clonal rearrangements in the T cell receptor genes lymphomas contain clonal rearrangements in the T cell receptor genes
enlarged spleen ( J:73487 )
• is often observed in necropsy due to lymphomas

cellular
abnormal cell cycle checkpoint function ( J:73487 )
• thymocyte cell size is significantly increased in these mice
• thymocytes express high levels of cyclin D2, D3,and E and promote progression through G1

endocrine/exocrine glands
decreased thymocyte number ( J:73487 )
• number of thymocytes is decreased by about 20% compared to wild-type mice despite the thymus having similar weight as in wild-type
• thymocyte cell size is significantly increased in these mice
increased T cell derived lymphoma incidence ( J:73487 )
• most mice die from lymphoid neoplasms
• lymphomas contain clonal rearrangements in the T cell receptor genes lymphomas contain clonal rearrangements in the T cell receptor genes

growth/size/body
enlarged spleen ( J:73487 )
• is often observed in necropsy due to lymphomas




Genotype
MGI:3833620
tg6
Allelic
Composition		 Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:144975 )
• mice develop thymic lymphomas and are moribund beginning at 5 weeks of age

neoplasm
increased T cell derived lymphoma incidence ( J:144975 )
• mice develop thymic lymphomas and are moribund beginning at 5 weeks of age
• all mice develop thymic lymphomas by 28 weeks

immune system
increased T cell derived lymphoma incidence ( J:144975 )
• mice develop thymic lymphomas and are moribund beginning at 5 weeks of age
• all mice develop thymic lymphomas by 28 weeks
abnormal T cell differentiation ( J:144975 )
• DN1 thymocyte numbers are increased while DN3 and DN4 thymocyte numbers are decreased compared to in wild-type mice

hematopoietic system
increased T cell derived lymphoma incidence ( J:144975 )
• mice develop thymic lymphomas and are moribund beginning at 5 weeks of age
• all mice develop thymic lymphomas by 28 weeks
abnormal T cell differentiation ( J:144975 )
• DN1 thymocyte numbers are increased while DN3 and DN4 thymocyte numbers are decreased compared to in wild-type mice

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:144975 )
• mice develop thymic lymphomas and are moribund beginning at 5 weeks of age
• all mice develop thymic lymphomas by 28 weeks




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory