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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pgia8DBA/2
DBA/2
MGI:3803903
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pgia8DBA/2/Pgia8DBA/2 C.D2-(D15Mit12-D15Mit267) MGI:3803909
hm2
 		Pgia8DBA/2/Pgia8DBA/2 involves: BALB/c * DBA/2 MGI:3803928


Genotype
MGI:3803909
hm1
Allelic
Composition		 Pgia8DBA/2/Pgia8DBA/2
Genetic
Background		 C.D2-(D15Mit12-D15Mit267)
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to induced arthritis ( J:137478 )
• resistance to proteoglycan-induced arthritis in female animals

skeleton
decreased susceptibility to induced arthritis ( J:137478 )
• resistance to proteoglycan-induced arthritis in female animals




Genotype
MGI:3803928
hm2
Allelic
Composition		 Pgia8DBA/2/Pgia8DBA/2
Genetic
Background		 involves: BALB/c * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-6 secretion ( J:137478 )
• 3-fold reduced IL-6 production in females
increased tumor necrosis factor secretion ( J:137478 )
• 1.5- to 2-fold increased TNF-alpha production during PGIA disease
decreased susceptibility to induced arthritis ( J:137478 )
• resistance to proteoglycan-induced arthritis in female animals

skeleton
decreased susceptibility to induced arthritis ( J:137478 )
• resistance to proteoglycan-induced arthritis in female animals




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory