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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ergmld2
multilineage defect 2
MGI:3803955
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ergmld2/Ergmld2 involves: 129S1/Sv * C57BL/6 MGI:3805478
ht2
 		Ergmld2/Erg+ involves: 129S1/Sv * C57BL/6 MGI:3805479
cx3
 		Ergmld2/Erg+
Mpltm1Wsa/Mpltm1Wsa 		B6.Cg-Mpltm1Wsa Ergmld2 MGI:3805474


Genotype
MGI:3805478
hm1
Allelic
Composition		 Ergmld2/Ergmld2
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ergmld2 mutation (0 available); any Erg mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:137835 )
• homozygous embryos start to die around E11.5; no embryos are recovered at E13.5

embryo
embryonic growth retardation ( J:137835 )
• at E10.5, embryos show evidence of developmental delay by half a day
abnormal embryonic erythropoiesis ( J:137835 )
• cultured yolk sacs from E10.5 embryos produce almost no colonies of any hematopoietic lineage

growth/size/body
embryonic growth retardation ( J:137835 )
• at E10.5, embryos show evidence of developmental delay by half a day

hematopoietic system
abnormal embryonic erythropoiesis ( J:137835 )
• cultured yolk sacs from E10.5 embryos produce almost no colonies of any hematopoietic lineage




Genotype
MGI:3805479
ht2
Allelic
Composition		 Ergmld2/Erg+
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ergmld2 mutation (0 available); any Erg mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:137835 )
N
• mice do not show anemia on a wild-type background
• adults do not have any gross abnormalities in thymus, spleen, bone marrow, pancreas, or lymph nodes; bone marrow and spleen cellularity is normal and so are numbers of morphologically recognizable hematopoietic cells
decreased transitional stage B cell number ( J:137835 )
• numbers are slightly lower in the spleen, typifying trend toward fewer B cells in peripheral blood, bone marrow, and spleen
thrombocytopenia ( J:137835 )
• platelet counts are lower than wild-type
decreased hematopoietic stem cell number ( J:137835 )
• in cultured single-cell suspensions, bone marrow and spleen produce fewer colonies than wild-type; progenitor cell frequencies of all lineage types are 50% of control

immune system
decreased transitional stage B cell number ( J:137835 )
• numbers are slightly lower in the spleen, typifying trend toward fewer B cells in peripheral blood, bone marrow, and spleen




Genotype
MGI:3805474
cx3
Allelic
Composition		 Ergmld2/Erg+
Mpltm1Wsa/Mpltm1Wsa
Genetic
Background		 B6.Cg-Mpltm1Wsa Ergmld2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ergmld2 mutation (0 available); any Erg mutation (27 available)
Mpltm1Wsa mutation (1 available); any Mpl mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:137835 )
• platelet counts are significantly lower than single Mpl-deficient animals
decreased leukocyte cell number ( J:137835 )
• at lower end of normal range

immune system
decreased leukocyte cell number ( J:137835 )
• at lower end of normal range




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory