About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ergmld2
multilineage defect 2
MGI:3803955
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ergmld2/Ergmld2 involves: 129S1/Sv * C57BL/6 MGI:3805478
ht2
 		Ergmld2/Erg+ involves: 129S1/Sv * C57BL/6 MGI:3805479
cx3
 		Ergmld2/Erg+
Mpltm1Wsa/Mpltm1Wsa 		B6.Cg-Mpltm1Wsa Ergmld2 MGI:3805474


Genotype
MGI:3805478
hm1
Allelic
Composition		 Ergmld2/Ergmld2
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ergmld2 mutation (0 available); any Erg mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:137835 )
• homozygous embryos start to die around E11.5; no embryos are recovered at E13.5

embryo
embryonic growth retardation ( J:137835 )
• at E10.5, embryos show evidence of developmental delay by half a day
abnormal embryonic erythropoiesis ( J:137835 )
• cultured yolk sacs from E10.5 embryos produce almost no colonies of any hematopoietic lineage

growth/size/body
embryonic growth retardation ( J:137835 )
• at E10.5, embryos show evidence of developmental delay by half a day

hematopoietic system
abnormal embryonic erythropoiesis ( J:137835 )
• cultured yolk sacs from E10.5 embryos produce almost no colonies of any hematopoietic lineage




Genotype
MGI:3805479
ht2
Allelic
Composition		 Ergmld2/Erg+
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ergmld2 mutation (0 available); any Erg mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:137835 )
N
• mice do not show anemia on a wild-type background
• adults do not have any gross abnormalities in thymus, spleen, bone marrow, pancreas, or lymph nodes; bone marrow and spleen cellularity is normal and so are numbers of morphologically recognizable hematopoietic cells
decreased transitional stage B cell number ( J:137835 )
• numbers are slightly lower in the spleen, typifying trend toward fewer B cells in peripheral blood, bone marrow, and spleen
thrombocytopenia ( J:137835 )
• platelet counts are lower than wild-type
decreased hematopoietic stem cell number ( J:137835 )
• in cultured single-cell suspensions, bone marrow and spleen produce fewer colonies than wild-type; progenitor cell frequencies of all lineage types are 50% of control

immune system
decreased transitional stage B cell number ( J:137835 )
• numbers are slightly lower in the spleen, typifying trend toward fewer B cells in peripheral blood, bone marrow, and spleen




Genotype
MGI:3805474
cx3
Allelic
Composition		 Ergmld2/Erg+
Mpltm1Wsa/Mpltm1Wsa
Genetic
Background		 B6.Cg-Mpltm1Wsa Ergmld2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ergmld2 mutation (0 available); any Erg mutation (27 available)
Mpltm1Wsa mutation (1 available); any Mpl mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:137835 )
• platelet counts are significantly lower than single Mpl-deficient animals
decreased leukocyte cell number ( J:137835 )
• at lower end of normal range

immune system
decreased leukocyte cell number ( J:137835 )
• at lower end of normal range




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory