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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irs1tm2Tka
targeted mutation 2, Takashi Kadowaki
MGI:3803974
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Irs1tm2Tka/Irs1tm2Tka
Irs2tm2Tka/Irs2tm2Tka
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA MGI:3805348
cn2
 		Irs1tm2Tka/Irs1tm2Tka
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129P2/OlaHsd * C57BL/6 * DBA MGI:3805350


Genotype
MGI:3805348
cn1
Allelic
Composition		 Irs1tm2Tka/Irs1tm2Tka
Irs2tm2Tka/Irs2tm2Tka
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm2Tka mutation (0 available); any Irs1 mutation (52 available)
Irs2tm2Tka mutation (0 available); any Irs2 mutation (37 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
insulin resistance ( J:137846 )
• under fasting and refeeding conditions

immune system
increased susceptibility to autoimmune diabetes ( J:137846 )
• mice develop diabetes
• however, over-expression of a dominant negative Foxo1 by adenoviral transfection improves diabetes




Genotype
MGI:3805350
cn2
Allelic
Composition		 Irs1tm2Tka/Irs1tm2Tka
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm2Tka mutation (0 available); any Irs1 mutation (52 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:137846 )
N
• mice exhibit normal hepatic triglyceride content, serum aspartate aminotransferase and alanine aminotransferase indicating a lack of hepatic injury
increased circulating insulin level ( J:137846 )
• mice exhibit higher serum insulin levels 4 and 6 hours after the start of refeeding unlike wild-type mice
insulin resistance ( J:137846 )
• mice exhibit insulin resistance under refeeding conditions
• however, mice do not exhibit insulin resistance under fasting conditions




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/21/2024
MGI 6.24 		The Jackson Laboratory