mortality/aging
• fewer than expected mice survive to weaning due to perinatal lethality
|
• some mice die after E17.5 and around birth resulting in fewer mice than expected at P21
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reproductive system
N |
• germ cell specification, migration, gonadal development and adult fertility are normal
|
homeostasis/metabolism
N |
• wound healing and fibroblast migration are normal
|
immune system
N |
• mice exhibit normal B and T cell counts
|