Phenotypes associated with this allele

• Allele Symbol: Rdh1^tm1.1Jln
• Allele Name: targeted mutation 1.1, Joseph Napoli
• Allele ID: MGI:3804065
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rdh1^tm1.1Jln/Rdh1^tm1.1Jln	B6.129P2-Rdh1^tm1.1Jln	MGI:3804208

Genotype
MGI:3804208

hm1

• Allelic Composition: Rdh1^tm1.1Jln/Rdh1^tm1.1Jln
• Genetic Background: B6.129P2-Rdh1^tm1.1Jln

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased percent water in carcass ( J:134843 )

• 15% less water and 28% less ash than in wild-type mice after dehydration and extraction

increased body weight ( J:134843 )

• despite same food intake, mice fed a low or deficient vitamin A diet weigh more than similarly treated wild-type mice

increased body length ( J:134843 )

• male mice fed a low or deficient vitamin A diet are longer than similarly treated wild-type mice

increased kidney weight ( J:134843 )

• 25% increase compared to in wild-type mice

increased liver weight ( J:134843 )

• 58% increase compared to in wild-type mice

adipose tissue

increased total fat pad weight ( J:134843 )

• epididymal, retroperitonal and brown fat pads weight 1.8-fold more than in wild-type mice while mesentery, femoral and inguinal fat pads weight 3.7-, 2.7- and 2.8-fold, respectively, more than in wild-type mice and are disproportional large relative to body weight

increased percent body fat/body weight ( J:134843 )

• despite same food intake, mice have 59% more fat and a 39% greater adiposity index compared to wild-type mice after dehydration and extractions

homeostasis/metabolism

abnormal retinol level ( J:134843 )

• when fed a high or marginal vitamin A diet, mice exhibit a 2-fold increase in liver retinol levels compared to similarly treated wild-type mice

• when fed a marginal vitamin A diet, mice exhibit a 40% increase in kidney retinol levels

liver/biliary system

increased liver weight ( J:134843 )

• 58% increase compared to in wild-type mice

renal/urinary system

increased kidney weight ( J:134843 )

• 25% increase compared to in wild-type mice

embryo

embryo phenotype ( J:134843 )

N • regardless of vitamin A content in maternal diet, mice develop normally