Phenotypes associated with this allele

• Allele Symbol: Rpl22^{Gt(GST000137)Lex}
• Allele Name: gene trap GST000137, Lexicon Genetics
• Allele ID: MGI:3804429
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rpl22^Gt(GST000137)Lex/Rpl22^Gt(GST000137)Lex	involves: 129S5/SvEvBrd	MGI:3805106

Genotype
MGI:3805106

hm1

• Allelic Composition: Rpl22^{Gt(GST000137)Lex}/Rpl22^{Gt(GST000137)Lex}
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell apoptosis ( J:123569 )

• alpha beta lineage T cell undergo increased apoptosis compared to in wild-type mice

thymus hypoplasia ( J:123569 )

• thymic cellularity is reduced to 1% of normal

abnormal T cell differentiation ( J:123569 )

• differentiation of alpha beta-lineage precursors into more mature double and single positive T cells is severely impaired and is arrested at beta selection

arrested T cell differentiation ( J:123569 )

• differentiation of alpha beta-lineage precursors into more mature double and single positive T cells is arrested at beta selection

• arrested alpha beta T cell development is dependent on Trp53 expression

• however, alpha beta lineage T cell development is cell autonomous and restored by ectopic expression of Rpl22

• alpha beta lineage T cells fail to differentiate to DN4 cells

abnormal T cell number ( J:123569 )

• while gamma delta T cell lineages are increased in proportion and absolute number, alpha beta T cell lineage proportion and numbers are decreased in lymphoid organs

decreased T cell number ( J:123569 )

• fewer CD44- CD25- DN4 T cells are present

• decreased T cell numbers are associated with increased apoptosis

• mice exhibit a reduction in both DN3 and DN4 T cells

decreased double-negative T cell number ( J:123569 )

decreased CD4-positive, alpha-beta T cell number ( J:123569 )

decreased CD8-positive, alpha-beta T cell number ( J:123569 )

glomerulonephritis ( J:123569 )

• mild

renal/urinary system

glomerulonephritis ( J:123569 )

• mild

hematopoietic system

increased T cell apoptosis ( J:123569 )

• alpha beta lineage T cell undergo increased apoptosis compared to in wild-type mice

thymus hypoplasia ( J:123569 )

• thymic cellularity is reduced to 1% of normal

abnormal T cell differentiation ( J:123569 )

• differentiation of alpha beta-lineage precursors into more mature double and single positive T cells is severely impaired and is arrested at beta selection

arrested T cell differentiation ( J:123569 )

• differentiation of alpha beta-lineage precursors into more mature double and single positive T cells is arrested at beta selection

• arrested alpha beta T cell development is dependent on Trp53 expression

• however, alpha beta lineage T cell development is cell autonomous and restored by ectopic expression of Rpl22

• alpha beta lineage T cells fail to differentiate to DN4 cells

abnormal T cell number ( J:123569 )

• while gamma delta T cell lineages are increased in proportion and absolute number, alpha beta T cell lineage proportion and numbers are decreased in lymphoid organs

decreased T cell number ( J:123569 )

• fewer CD44- CD25- DN4 T cells are present

• decreased T cell numbers are associated with increased apoptosis

• mice exhibit a reduction in both DN3 and DN4 T cells

decreased double-negative T cell number ( J:123569 )

decreased CD4-positive, alpha-beta T cell number ( J:123569 )

decreased CD8-positive, alpha-beta T cell number ( J:123569 )

cellular

increased T cell apoptosis ( J:123569 )

• alpha beta lineage T cell undergo increased apoptosis compared to in wild-type mice

endocrine/exocrine glands

thymus hypoplasia ( J:123569 )

• thymic cellularity is reduced to 1% of normal